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I agree, totally trial and error. it will work well for some people and not for others. And I think it's important to work closely with your Dr and to also start on the smallest dose. And to cease it it you have any unpleasant side effects.
A Dr prescribed me Reductil when it first came out so we're going back about 9 or 10 years here. I wasn't on it for long, it sent me bonkers. Really moody and I would wake up feeling really agitated and aggressive. I'm glad it was taken off the market. Luckily no such side effects with Duromine for me.
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My gf on it, takes it every 2nd day (under advice of Dr, effects of tablets last 1 1/2 days).
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A friend of mine took it every 2nd day as well and had good results.
Please keep in contact with your Dr while you're on it. Also, my dr told me to keep the actual script in the car with you while you're driving because she said it might show up in some drug tests the police do nowadays.