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Thread: IVF with PGD # 10

  1. #37

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    Wow Elle that has certainly gone fast! Feeling the movements are one of my best memories when I was pregnant the first time around. Good luck with your scan next week.

    Just trying to get past the weekend with my bt on Tues. hard to tell what is going on as on crinone and had my last jab of hcg this morning so there is no way I will be able to poas before then


  2. #38

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    Hi Girls - well, what a couple of days I have had my goodness! So, Monday I went back to the GP with my coughing and sinuses, as suspected sinus infection, antibiotics (safe ones) and off I go. Tuesday morning I wake up after a night of coughing and I have a rotten headache, very nauseous, dizzy, weak, feeling really weird - panicked about a reaction to the antibiotics so DH took me to the local hospital at 10am, I was in such a bad way I seriously thought I was dying at one point. Thankfully I was so bad they fastracked me and took me straight in. The doctor was scrumptious, please remind me not to wear my orange knickers and do my face and hair next time, at the time I did not care however lol. But they tested me, poked me did all sorts gave me loads of painkillers (all the while knowing I was supposed to be going in for collection today, yes today!) - I triggered Monday night. So long story short had to have a CT scan and a lumber puncture (not fun) to rule out meningitis, all clear so they put it down to a sinus migraine. So, 11.30 pm I got let out, after NO food yes NO food ALL day argh! Came home at midnight, got 5 hours sleep and had to get up and be at my clinic's hospital for 6.30 am, I was first on list and went in at 7.45 am yay! I cannot believe I made it, seriously ,nothing and I mean nothing was standing in my way today. So, I had 5 follies, 2 better than last time - was hoping for 1 or 2 more on the Menopur but never mind they were happy with that, triggered Monday night, got the 5 today but unfortunately only 4 were mature, shouldn't say only as it could've been worse I know. So tomorrow I find out fertilization rates (ICSI again so fingers crossed), they will thaw my other 3 embies and testing will be sent off and done Saturday and hopefully praying praying that I have something decent to transfer next Tuesday! EEEK. I am sooooooo nervous about it all, losing them in the thaw, not dividing, not being cleared in testing, not making it to day 6 yada yada so here is the real stuff eh. I am in a bit of pain tonight, moreso than last time, ouchy ovaries and a sore back from the lumber so I will just have to try and convince DH it's real and I have to take it easy, not so simple with a 3.5 year old but I have to. So girls, starting the Crinone tomorrow night, how does it differ from the usual pessaries I was taking in the luteal phase of a natural cycle?

    What shall I expect, how do you get through these next days sane, or don't you? Eeeek all these questions! Anyone know the average loss rate with testing? I'm expecting a good half from what I read boo hoo. I'd love to prove them wrong.

    How is everyone else going??

    xx

  3. #39

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    Oh my Alison, you have been through the ringer! Know it wasn't fun at the time but thankfully it was only a sinus migraine. How many have you got frozen? They really do wonderful things in the lab now so fingers crossed they all thaw nicely. Wishing you magical numbers. I have felt like poo since my epu last Monday. Felt like I had been ripped apart with my ovaries all twisted up. Obviously not but quite painful. Needed Panadol for the first couple of days. Feeling really full in the belly now with a dull backache. Taking Crinone twice daily with hcg 1500 U on days 3, 6 & 9. Actually tolerating it a lot better than the prog pessaries I took with my last FET. Good luck with the testing & hope the next week isn't too hard on you xxx

  4. #40

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    Thanks JoeSpratt - feeling a tad better in the physical sense this morning, but deflated in the mental sense. The lab rang, out of the 4 mature eggs they got yesterday only 2 are showing signs of normal fertilization (with ICSI) - one didn't fertilize at all and the other is showing signs of abnormal fertilization. Sigh. Last collection we only got 3 eggs but all 3 fertilized so I was expecting at least 3 of the 4 so very bummed. We have 3 on ice so what this means is providing these other 2 start dividing today it means we will only have 5 to send to testing - they said best going with a minimum of 6 to make it worthwhile so we have to make a decision. Just spoke to DH, he said for the sake of waiting another 3 months to do another cycle/testing (as it seems to take that long) for the possibility of getting extra to make up the 1 for the miminimum is it really worth it. Ie, we could end up with no fertilized eggs next time you just never know. So the question is, do we take the chance with the 5 or go another round in the hope we get more. I am so bummed I really thought this was it. Maybe I'm just not going to get my wish of another bub after all.....they said to me once 70% of all eggs tested will be non viable so 70% of 5 gives me 2 left - I'd be happy with 2 normal eggs, hell I'd probably be ok with 1 but 2 means i'd have a back up if the first didn't take, but of course the more the merrier. I'm so at a loss as to what the right thing to do is, ho hum. xxx

    So what side effects shall I expect from the crinone???

  5. #41

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    Don't despair Alison...this last cycle I got 9 but only 7 were mature enough for ICSI of which only 5 fertilised (seeing a pattern yet?!) & only 4 were good enough for testing. We only got 2 normal but only 1 made it to a blast. My previous cycle I got 9 with 8 mature for ICSI of which only 6 made it to testing. We still only got 2 normal with 1 resulting in our DD5 & the other was never to be, forever an angel. The numbers game sucks poo! It only takes one & I am holding onto that hope like nothing else.

    In regards to the Crinone, the only side effect that I have really had is discharge but nowhere near as much as with the progesterone pessaries. Haven't felt normal since starting this cycle. Feeling really full in the belly & extremely thirsty.

    Best of luck with whichever way you go xxx

  6. #42

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    Double post sorry!

  7. #43

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    Hi girls

    This is a super quick one because I have to run (don't even really have time to write this but oh well, haha...) -

    Alison - So sorry about your tumultuous couple of days. I swear, you couldn't even make that stuff up... Crazy! I just wanted to let you know that I didn't have the best numbers and the numbers themselves don't necessarily mean it's all over, or it's not going to happen, it can't happen etc. Long story short, I had 4 embryos make it post-biopsy (after 2 cycles, at 30 years old, just very poor response to meds - my body does not seem to like the intervention). It was our only shot and we went for it and hoped and prayed for the best - we had 6 little embryos, we knew from biopsy that 2 weren't looking the best and 4 seemed ok - so basically 4 embryos. The testing we had done was for a known genetic disease (that DD has), 25% chance of being affected, 50% chance of being a carrier. We had **3** come back completely unaffected. I am pregnant now with one of those little ones. The numbers just don't mean everything. I know we were incredibly lucky, and I know we are in different situations, but my point is, who is to say you won't get lucky...!? Do you know what I mean? Obviously, there are difficult decisions to make for you, and I know the waiting is beyond awful - I was a wreck, especially the morning of a potential transfer not knowing if there was even going to be a transfer (results came through that morning). I cried so hard on the phone to the embryologist I swear she probably had no idea what was going on with me. It is just a very difficult time all around, no denying it - but all hope is not lost, it really isn't. I don't know if any of that helps or not, but wanted to try... I'm sending you big hugs!

    As for the Crinone, I did not know what symptoms I was getting from what - I felt very achy and extremely bloated post-EPU and started Crinone that night, so not sure how much to attribute to the EPU. So for me, basically for at least 5-6 days post-EPU I was feeling pretty awful (to the point where I worried something was going wrong and transfer would be cancelled). Laying down with heat packs was what helped me the most. Also drinking lots of water (helps with fluid retention in abdominal area). I was so bummed when the nurse told me no heat packs after transfer, I wondered how I was going to get through without them. I had probably about 2-3 days of feeling ok post-transfer (still on Crinone) and then started getting very achy/crampy again but with extra pain in my lower back/tailbone area. In retrospect, that would have been right around implantation. I think it's just a time where you will, unfortunately, be feeling very emotional and uncomfortable... but it will pass. I didn't find the Crinone a worry personally, I just found the whole process very draining. Be kind to yourself.

    JoeSpratt - Wishing you a happy and peaceful few days and wonderful results on Tuesday!

    Yep, now I'm late, haha.....

  8. #44

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    Oh Girls thank you so much for putting my mind at ease, I'm so grateful I have you all to lean on with your own experiences and all. Thanks for giving me hope!!!

    Well the clinic rang this morning, my 2 from yesterday have made it to today, one is at 3 and one is at 4 cell so they are very happy with that. My first 3 frozen embies are being thawed today in preparation to be sent off for testing tomorrow, I'm so nervous about losing those ones in the process. She said you can lose up to 30% in the thaw so I am crossing everything that they all survive and all continue to divide. She was happy with having 5 to send to testing, I am quite amazed at the difference between speaking with the embryologist as opposed to the nurses/specialists etc as they've always said 6 - but she said 5 is good, even 4 is ok so I'm feeling a bit more optimistic. Look at the end of the day, like I said to her, we could wait another 2/3 months, spend another $10,000 on another cycle, get 0 or 10 eggs and none be ok still so we have decided to just go with the gamble and hope for the best. This is going to be a nervous wait, gah........obviously the more the merrier but my ultimate would be to end up with 2 good embryos by next Tuesday so I can freeze one for backup - but I won't count my chickens before they've hatched. I'm going to be devo if they all peter out.

  9. #45

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    Oh Girls thank you so much for putting my mind at ease, I'm so grateful I have you all to lean on with your own experiences and all. Thanks for giving me hope!!!

    Well the clinic rang this morning, my 2 from yesterday have made it to today, one is at 3 and one is at 4 cell so they are very happy with that. My first 3 frozen embies are being thawed today in preparation to be sent off for testing tomorrow, I'm so nervous about losing those ones in the process. She said you can lose up to 30% in the thaw so I am crossing everything that they all survive and all continue to divide. She was happy with having 5 to send to testing, I am quite amazed at the difference between speaking with the embryologist as opposed to the nurses/specialists etc as they've always said 6 - but she said 5 is good, even 4 is ok so I'm feeling a bit more optimistic. Look at the end of the day, like I said to her, we could wait another 2/3 months, spend another $10,000 on another cycle, get 0 or 10 eggs and none be ok still so we have decided to just go with the gamble and hope for the best. This is going to be a nervous wait, gah........obviously the more the merrier but my ultimate would be to end up with 2 good embryos by next Tuesday so I can freeze one for backup - but I won't count my chickens before they've hatched. I'm going to be devo if they all peter out.

  10. #46

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    You will never know if you don't give it a try! Strange how you get such Different perspective by talking to different people at the clinic. At least you now seem more at ease with your decision. Best of luck with the thaw & testing xxx

  11. #47

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    If it's one thing I have learnt JoeSpratt it's that you just can't believe/listen to every single thing they say because they all tell you different things, make you feel different ways, it just depends who you speak to I guess. I think it's what makes the whole IVF process so bloomin stressful!!!!!! Us girls deserve a medal, how anyone gets pregnant naturally is beyond me, I am convinced my daughter was pot luck! xx

  12. #48

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    Alison: gosh what a rough time you are having ! Fingers crossed that your two little ones are doing well tomorrow and your frosties thaw ok, I was told you lose 25% in the thaw, I had 11 thawed and 9 survived.

    Also I had 10 tested and only had one good one and it is going well but they told me those were bad results so I hope you do a lot better

    Joe: will you poas early ? Good luck to you

    Elle: good to see you popping in, good to hear all is going well

    Afm: I have my big scan on Wednesday, still unsure if we are going to find out the sex, part of me wants the surprise, part of me wants to know.
    Unfortunately I have already developed gestational diabetes so I'm on insulin, after everything we have been through I could have done without that complication but as long as we are both well I'll cope !

  13. #49

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    Minnie life certainly isn't easy for some of us. Good luck for your scan next Wed. At least GD is so manageable these days. Interesting they put you straight on insulin though. Have you had GD before?

    No poas for me. Only had my last HCG shot on Wed so that will probably only have cleared by Tues in time for my bt. Question for anyone though...if the embie has failed to implant, is the amount of Crinone you take daily enough to keep AF at bay until you stop. The packaging says 90mg per shot & taking morning/night.

  14. #50

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    Joe: yes I had gestational diabetes last time and was on insulin at 26 weeks so the endo has been watching me like a hawk and as soon as my blood sugars started creeping up he put me straight on insulin. I have a complicated endocrine history including pcos, insulin resistance, thyroid problems, high prolactin levels etc I knew I was at high risk to get it again and I proved them right !

    As far as crinone, I have never gotten af before the blood test but my levels seem to go quite high and it takes a while to wean off the crinone but I do know some people do get af before its due, I guess it depends on your body which probably doesn't help you !

  15. #51

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    alison - even by ivf/ttc standards, you have had it quite rough this cycle. i am going to hope for at least one little embryo for you (2 would be a bonus of course...), but even just one would be great. i think ive mentioned it already, but i got 7 to biopsy & 2 tested normal. i remember being so relieved that i even got one, its such a stressful process. xx

    joe - how frustrating you cant poas... torture! i replied to your question in the other tread, but crinone didnt stop af for me. usually af arrived 1-2 days before BT, regardless of the dose i was on. how are you feeling?

    hi elle & minnie - nice to hear that things are going well for you both. look forward to hearing about your upcoming scans in the next week or two.

  16. #52

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    Hi Girls!

    JoeSpratt - interesting question re the Crinone I was wondering the same myself? I am nervous as I have low progesterone also so hoping this is enough - what's the difference between the Crinone and the other progesterone pessaries they usually put you on for luteal support?

    Minnie - wow scan time already that is SO exciting - I wouldn't know what to do either, I have told myself that if I manage to get pregnant I think I will find out, I've had enough surprises but then again I will probably change my mind. I had a surprise with my daughter and I loved it. Good luck, can't wait to hear all about it.

    Andie - goodness me are you 30 weeks already? Where did that time go!!!!!!

    AFM - well, sombre mood here today, embryologist phoned and we lost one of the 3 in the thaw yesterday which is so disappointing so now we only have 4 to send for testing, really not ideal but we decided to chance it and go ahead. To say I'm feeling nervous is an understatement, I know my chances are not great now but I decided enoughs enough and it's time to move on with life regardless. Of the 4 that remain 3 are at 7 cell and one at 5 cell today and 3 are graded at 2's which she said is the best you can get on day 3 so feeling happy about that so far at least. The other she said is in between dividing so while it was a little behind it was too early to put it down to anything bad, that one was graded at a 3. So girls, because it's Saturday and I'm in Perth I won't get the results back until Tuesday morning which is the day of transfer, how the hell am I going to stay relaxed between now and then! I really really wanted 2 good embryos so I had one as a backup but I'm thinking I'm going to be bloomin lucky if I get one now. I don't know how to feel, confused, sad, excited, apprehensive, angry at my eggs - gah so many emotions.

  17. #53

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    Know how you feel Alison! Didn't get the results of my testing until day of transfer either. Worse still, as the surgery was a 3 hour drive away, I got the call while driving down the freeway. They figured they could at least save me a trip if it all went pear shaped. Just tried my best to keep calm & keep the anxiety levels to a minimum. Easier said than done I know & I won't lie, there were quite a few tears shed on that drive.hoping you get a great outcome though. Looks like Tues will be a big day for both of us! Would have been the due date of my angel from my last transfer last year so hoping that that is more than a coincidence & that we both get some fantastic news xxx & hugs

  18. #54

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    argh JoeSpratt how awful is this wait! I just can't relax I feel doom and gloom and nothing else. How are you supposed to feel positive in this situation. I wish I hadn't googled so much my odds going off stats aren't looking great. Ironically like yourself on Thursday it will be 12 months since my last miscarriage due to a blood clot (normal chromosomes) so I'm a bit on edge atm. Fingers crossed we both get the results we are hoping for tomorrow xxx

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