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:hello: Sara
I used 6 last cycle and 5 this cycle. Clinic told me my FS will not start it until there is a 13mm follie. If you had a lead one early on, they might have started you sooner? Could ponder that this might explain why they also gave you the Pregnyl, as the Orgalutron was keeping your LH levels so effectively low and they wanted them to float a tiny bit higher. Sort of a balancing act IYKWIM.
Thank you WTH, that's really good to know, I think they may have started me on the Orgalutron too early as I started it before I had my first ultrasound as no ultrasound was available on New Year's Day. Will insist next time to have an ultrasound first.
Sara
Meredith, I hope the new year and this new cycle soon will re-new your energy and give you that sth. you've been longed for...
WTH, hey we will be passing each other on the highway tomorrow, we are driving down to Jervis Bay, hehe, will wave you a good luck hun! All sounds good and super, 21 follies, you go girl and I hope you get lots of eggies!
Kel, hope all went well for today and you are now just resting! I hope you are not in Sydney because today is just steaming hot!!!
Sara, are you surviving the heat? I hope you are in the office. Friday is my off-day, so DH sent me to do a manicure and pedicure before our holiday also it is cool with the air-conditioning, how sweet! Now we are home, I miss the coolness in the office....;)
Ok, girls, I will be offline during this long weekend and probably won't be back until Monday night, so wish you all good luck and I shall look forward to some exciting news!
CP - your DH is very sweet - have a great break.
Sara
Hi everyone,
EPU went well, they retrieved 19 eggs. We'll know at about 0730 tomorrow how many fertilised. I'll have to do personals later, I'm pretty sore. I hope you're all well.
Kel - well done on 19 eggies. No wonder you are a bit sore. Hope you get great result tomorrow and can then survive the long wait until wed
Sara - 8 shots did sound a lot. Maybe was started a touch early. My clinic uses the 13mm rule too although seemed to ignore it with me this time - I had a 13 and 12mm follie but they waited another day to start. They do say it can slow things down a bit so not sure or if they were jut being nice and trying to save me $$$?!
WTH - wow, amazing what a difference 1 day can make. 21 follies - pitty they didn't show their faces earlier. Ayway, sound like you hould have at least 7 good ones for tomorrow. Wishing you all the best on this every start of a loooong week
CP - Hope you have a really nice weekend.
AFM - feeling pretty down about it all today. My follies are going great guns with massive growth over 2 days despite the lowered FSH. I now have about 16 between 12-18mm with most 14-16mm.
My lining, however is terrible - left the u/s in tears over it. Hasn't changed at all in past 2 days and barely at all since first scan.
I have never fallen pg with a lining under 6mm and currently at 4.7mm. Mind you, last cycle was my best ever reaching 7mm and I didn't get pg so who knows if that played any part in previous failures.
Bless my nurse, she knew i would be worried o had already talked to my FS. They are not happy with lining but don't really have any more tricks left to help. Going to try vaginal progynova( oestrogen) but not holding any hope since my E2 is 7000 so doubt adding any more is going to make any difference. They are holding off EPU until tues to try and give it some more time. At least all my follies will be of great maturity ( prob better than last time) but really thinking if it hasn't thickened at all yet, that it prob won't change. I think the chances of getting pg with thin lining is pretty slim and I am sooooooo worried as to why and if it can ever be better. Not much point getting great eggs and embryos if there is no oven in which to bake them. Sorry to be a sad sack but really feeling my dreams slipping further and further away today.
Meredith - stalking you and sending you a cyber hug :hug: I wish there was something I could do :(
Kel: Well done, that's a great number, keeping fingers crossed!
Meredith: :hug: Sorry that you have trouble with the lining. It's easy for me to say but the only thing I can see you might be able to do is to concentrate on things one step at a time. Your egg numbers sounds great especially that they're all so close together. So try to concentrate on EPU and fetilisation. Et is only the next step after that. If worst comes to worst and your lining does not get better there is still the option not to do a fresh transfer this time and to freeze them. As was said before in this thread that seems to be what's always done in Japan so there may be advantages in a frozen transfer. Thinking of you.
WTH: Good luck this morning. :goodluck:
Sara
Hi all,
I'm sick as a dog after EPU so I'll do personals later, but 16 eggs out of 19 fertilised, so today we have 16 embryos. I'll find out on Monday how many kept growing. Hope you're all well.
Meredith - :hug: Darn lining. I had really hoped things would pick up for you by now. "Ditto" basically everything Sara said - I am sure it must vary from month to month so worse case scenario you can transfer on a frozen cycle where the lining is better. Completely understand how this has upset you, hon. Will they keep scanning after EPU?
Kel - :clap: Bravo on your amazing egg number and fertilisation result. My Dr this morning said 60% was the standard fertilisation rate so you have done incredibly well. Rest up. Hope the pain eases quickly.
Sara and CP - :hello:
AFM - Up at the crack of dawn for EPU this morning. Managed 10 eggs. Dr only did the larger looking follies (there were many small ones).
7 Grade 1, mature
2 Grade 2, possibly immature
1 Grade 3, immature
Last cycle was 7 Grade 1 mature, so realistically quite similar.
Feeling no pain this time :D, just quite tired. Will keep you all updated
WTH: That's really great, from possibly smaller numbers now up to 10! keeping fingers crossed for fertilisation.
Sara
WTH FERTILISATION REPORT
Turns out one of the :egg: had a "fractured zona" so only 9 were put with DH's swimmers. AND.....
6 :fertilise:
A greedy 7th eggie managed 2 sperm
Trying not to get ahead of ourselves, but feel things seem to be going a bit better this time...
HAPPY AUSTRALIA DAY, EVERYONE :)
Happy Australia day to you too!
WTH - very happy that things are going so well for you. Go embies go!
Sara
Kel - 16 embies is fabulous result. Surely there has to be agoodie in amongst that! Hope you are feeling a bit better post EPU
WTH - 6 embies is fabulous ( how many last time?). Just gotta keep them growing strong until biopsy day. Will that be Thurs? Glad you are feeling so positive. lets keep the hatrick theory going.
Sara and WTH - thankyou for your kind words. Wish i could say i was feeling more positive but not really. They will chk lining again at EPU and pending that not sure if might want to look again before ET day. I would be very reluctant to skip ET even if chances are slim. I had no frosties from 14embies last cycle so certainly not putting any hope/faith in frozen embie cycle. Would probably prefer to just give it a shot and pray for some sort of miracle. Triggering tonight. Should be feeling more excited by it all but just to frustrated with my stupid body!
Hi everyone,
Well we started off with 19, 16 fertilised, and today there are only seven left growing and they're all grade two. The lab told us that realistically there is probably only going to be two or three suitable for biopsy by Wednesday, and that this was pretty normal for translocations. I've also ended up with OHSS again.
I'm really disappointed that more didn't make it. Any advice? Was I being unrealistic to expect higher survival percentages?
WTH: Congratulations on your numbers!
Meredith: GL for tomorrow, hon.
Hi everyone I mised.
Hi Kel,
Sorry about the OHSS. I hope things improve quickly for you.
Are your translocation issues likely to affect survival - in other words is it likely that the ones that have stopped growing have mostly stopped because they were affected in the first place?
THere is nothing you can do about this step of the process - which makes it so very hard. Look after yourself, and do some nice things if the OHSS will let you
hugs
Kate
Kel, afraid I can't offer advice on survival rates - I'd be guided by your clinic on that one. Bugger about the OHSS, I've been there before and I know it's not pretty. Will they let you transfer if there's anything suitable? I can give you some tips on avoiding OHSS for next time if it becomes necessary - if you would find that helpful. I developed it twice and had my FS almost resigned to "this is just what your body does", but with a scarily strict diet we managed to avoid it on the third stim cycle... at least until the embryo took! Hang in there, I'll be hoping and praying for you that there's not only embryos suitable for biopsy, but there's a good one in there to be transferred. :hug:
BW
Hi Kate: Yes, the translocation can affect the survival rate because of anueploidy of the affected chromosomes. I'm assuming that monosomy occurred (as opposed to trisomy) due to the immediate arrest in growth; so it is probably safe to say that it was the reason that nine embryos stopped growing. That said, I would much have preferred (as I'm sure everyone would) that more than seven embryos had a chance. I'm just having a hard time getting my head around only two or three of the embryos out of 19 possibly making it to Wednesday, let alone through PGD. :cry: