IVF with PGD #5

PS- The technology in this age is AMAZING, it is one of the reasons we decided (after a moral struggle) to use our carriers, imagine what they can do in another 20-30 years when our children are ready to have children!

Hi Jaki,
Sorry for the late reply, I've been on a conference in New Zealand. Went skydiving today, was unreal! Home tomorrow early morning.
As for IVF, I'm still on synarel although starting puregon Wed if everything is ok with my downreg scan tomorrow... EPU planned for Mon 5th July. What are you up to at present? Have you had a transfer yet?
Hope all is going well!
I think that totally makes sense about the carriers... who knows what our kids will be able to do? They'll probably be growing babies in test-tubes then anyway!!! (although people have thought that for at least 50 years!)
Let me know how you're going and I'll try and be a bit prompter to reply!
Susi

New Zealand WOW, what a great way to break up the monotony of an IVF cycle!
Im great, still just waiting for period to get here so i can start injecting. Got all my meds on friday so im all set to go!
I'll jump on and let you when when i start!

Started injecting on thurs! Yay!
BT on monday.

My husband and I are going through PGD with IVF. I have a chromosomal paracentric inversion that's causing miscarriages. We're at MIVF.

New to forums...thought it'd be nice to "meet" some other women going through the same thing. :D

I think I am a week or so ahead of you all in my cycle??? Not sure. We are having our trigger shot tonight! I've got 10 follicles - the numbers went from 6 to 7 to 10. OPU on Monday! Oh my! It all goes so fast in the end.

Best wishes to both of you in those last few days of injections...and getting those follicles mature!

I'm a bit of a stalker of this thread. Always wishing good things for your ladies cycles!

Just wanted to say to Mia's Mama- I love your name! Very very cool. Good luck with your cycle.

(and now i will gracefully retreat again)

Kate

Hi Ladies.....
Mias mamma how did your collection go? You must be through the PGD now too.
Sorry ive been slack, i found belly belly became an obsession on my last cycle so ive been taking it easy.
I have another u/s tomoz, my result at the first were i had lots of follies between 10-13mm. Coming along quite nicely.
xx

Hi there Jaki80 and Kate07,

My first cycle we had no luck. 7 eggs retrieved, 6 fertilized, all had chromosomal abnormalities. Sucks big time!
Jaki80, if you don't mind my asking...if you were/are taking Puregon, what dosage? Sounds like this cycle is going really well for you! Congrats and best wishes in the next week.
I am thinking if we do PGD again I will ask for an increase in dosage to increase the amount of eggs...anything to up our odds!

A messy house is calling!

Hi mia's mama. I am on 150 units. But each person and cycle varies... for example. Cycle 1 i was on 150 and it got decrease as my hormones were to high. Cycle 2 i started on 150 which got increased to 250 in the last few days. This time i am going steady on 150.
Some people get alot of eggs and some get hardy any, im not sure why it is like that but i wish you could get tons without overstimulating. I overstimed on my first cycle and let me tell you it sucked! And as a result all my embies did not survive long.

Im sorry your PGD did not bring better results. If your anything like me those results will make you see how scary a natural conception would be when we carry these conditions :(
Dont give up!

I had another u/s today and will go again on monday.... If i were to make a bet i'd say egg pick-up on weds morning :)

xoxo

Mia's Mama - Sorry to hear that your first cycle wasn't successful. Unfortunately you had similar results with your PGD as me. My first cycle we got 10 eggs, so on my second cycle my doctor increased the meds (I was on Gonal F) and we were aiming for 20 eggs (although he told me not to tell people that because they are not meant to aim for more than 12ish, lol). We got 21 eggs from the second cycle. From those eggs we got our one perfectly healthy, chromosomally normal little girl that I'm now pregnant with. Good luck with your next cycle!!!

Jaki - Good luck with your ultrasound on Monday!

Mylitta - Your story seriously gives me some hope! My daughter was also conceived naturally and we had no idea of this "problem" until the repeat miscarriages started happening.

Jaki80 - I keep reading the same things with the injections - all women react differently! I was on 225 and went up to 300 the last two days!!! Holy cow, right?! No side effects though, so no probs. Thinking of you come Monday and all the best for Wednesday!!!

After this first round of PGD, I talked with the geneticist and he thinks it's not my chromosome problem causing the miscarriages - just BAD LUCK! Not sure if that good or bad. good and bad maybe? geez.

Have a good weekend!

Hi ladies, just a quick update. Had EPU yesterday... 15 eggs collected. Of that 13 were injected with sperm and this morning we have 11 'normal embies'. So excited.
Now the next hurdle is them making it to day 5-6 hatching into blasties and the pgd testing.
The average is 50% make it to blasties... Our first cycle we had 0% and our seccond 30%. So this time I'm praying for 50%!! hehe

foxy what is happening with you???????

Xoxo

Hi Jaki and Mia's Mama,
Sorry I haven't been around! I am a terrible forum-poster, I know!

Basically my ovaries responded really poorly to this cycle, and I got freaked out - it didn't look as though I was even going to make it to EPU! I was on 600 units Puregon, so your 300 doesn't seem too bad Mia's Mama! My FSH must be sky-high, which sucks given I'm only 32, nearly 33... Had EPU yesterday, finally, and got 10 eggs, much better than it was looking early on but probably not enough for PGD. I'll hear from the scientists tomorrow; MIVF does PGD on Day 3 embryos so may be a transfer tomorrow or Saturday. I guess 'cause we don't have to do PGD, if there are only 2 embryos, I'll just be putting them back without PGD; 6 embryos (unlikely given my track record, but here's hoping) and we'll do PGD but 3-5 embryos, I'm not sure. I'll have to get their advice I guess. The cost is huge so weighing up cost vs. 1 cycle of fresh embryos and 1 cycle of frozen embryos is hard... What would you ladies do if you didn't have a genetic condition, just failed repeated cycles?

Good luck for your blastocysts and PGD Jaki! 11 embryos is great!!! I hope they find a "normal" one in there, the chances are really good!

Mia's mamma, have you had EPU yet? Good luck!!!

Foxy77 - 600! Wow, I am impressed :). I had 10, 7 were mature and 6 fertilized, they were all tested and all had chromosomal problems. It was a HORRIBLE first result for us. I am 33 and just so surprised about having so many "bad eggs". It's a tough call for you - whether to test or not - think of both possibilities and which would be easier on you. We're also at MIVF and I am very familiar with the $$!

Jaki80 - Good news! I hope they get some good ones for you! 50% would be wonderful.

I'm trying to decide (with help from hubby) whether to do PGD one more time...then, leave it on God. We'll just continue to try naturally until menopause! LOL.

I'm trying not to write to much cause I'm on my iPhone which is annoying in a full size site. Lol

foxy- I really don't know what I would do but I do remember my last cycle I was upsets as I thought I'd have no blasties again and I demanded a transfer with out the pgd. At the very last minute I had 3 embies hatch out. The strongest of my 9 embies which would have been transfered without the pgd was the only one affected with my bad gene. That scared the you know what out of me for future cycles.
But.... Our reasons for pgd are so different.
I hope you get your transfer soon! Make sure you keep us posted!

Mia's mama I don't know what to tell you either, it is alot of money to keep going on. We are lucky in a way because we are forced down this track anyway by my husbands infirtility. I believe in fate, I never wanted children with my desease, I've seen too much suffering in our family already.

Also I want to give a shout out to Ferrals4. I'm not sure if you are checking in on this thread but if you are... I notice your signature says you are underway with another Ivf cycle! Are you doing pgd again??

Xoxo

Just another update... Yesterday got the day 3 embryo update.... I'm totally amazed at the difference between this cycle and my previous 2. We have....

2 embies at the grouping stage so they with hatch early by the looks.
8 embies at 8 cells
1 embie at 7 cells

the embryologist said they are beautiful and she's not seen such good embryo's in a long time!

I'm so used to getting bad reports it's so strange!!!!!

Foxy- did you get a transfer????????????

Xoxo

Jaki, how fantastic are your embies going?! That's great! Are they doing the biopsy and testing today? Will you get the results today as well? I was really impressed that on day 3 we would get a call in the late morning to tell us how many embies were going to get tested, and then a few hours later we would get another call with the results. But I guess it all depends on what is being tested for. Ours was pretty simple and just involved them staining and counting how many of each chromosome were present, so probably a lot quicker than a lot of testing that gets done.

Anyway, all the best over the next few days! I hope these are all healthy little embies and continue to grow well so that you can have a transfer and even have a few little frosty bub's!

EDIT: Oh, I was just going to add that some of my embies that got tested at day 3 were only 5 cells, so it just goes to show how well yours are doing!

Hi, Sydney Ivf will only biopsy blasties so that is day 5 or 6 embies if they hatch out. They believe it is better for the potential baby to take the biopsy from what will become the placenta rather than from the actual genetic material of the baby.
Our test is rather fast too, just a couple of hours and in I go. So hopefully I will get the call tomoz!