MTHFR homozygous C677T

Hi everyone,

I haven't been on here for a few years!

I just found out I am homozygous for the MTHfR gene, C677T. I have started reading on the net and have read lots of conflicting information regarding folic acid. In Australia it seems normal OTC folic acid is prescribed, whereas in the US, they use a more easily absorbed folate (which you can't seem to purchase here). If anyone else is homozygous, what have you been prescribed?
I guess what I really want to know is if there are any successful, healthy babies born from this? I have had two miscarriages and one full term baby (that one was IVF) who has a few congenital anomalies (but is otherwise awesome!).
Any and all information would be so appreciated!

stellasmum

I have compound heterozygous MTHFR. i am yet to have a live baby. I buy activated folate from the US. Thorne Research also do an activated folate you can buy in Australia. The advice is to not take folic acid at all. It can actually cause damage. Take activated folate, also called Metafolin and methylated folate. I got most of my info from Ben Lynch's site in the US.

Wow, I'm really sorry to hear that. Do you attribute the sad losses to mthfr?
Wishing you good luck in the future...

Also, if you don't mind me asking, which folate are you taking? I have just ordered the solgar 400. How much is suggested for this type of folate?

I'm taking the Seeking Health brand. The sublingual tablets have 800mcg metabolin and 1000mcg activated b12. I take one a day. I also take a multivitamin which has some metafolin. Same brand.

A good place to buy things from the US is iherb. They are a lot cheaper and have good shipping rates.

We don't know if the mthfr contributed to our boys or not. As mthfr can alter DNA in a developing foetus, then maybe. We don't know the mthfr status of the boys and my DH hasn't been tested. One, because it wouldn't make much difference to babies so long as I am taking activated folate and two, because knowing could affect his life insurance. I don't know if I want to know that's what killed them. It doesn't bring them back and I'm doing all I can do now I know about the mthfr.

It's also recommended to take low dose aspirin, as mthfr can contribute to platelets aggregating, but I am intolerant to salicylates so I'm researching another option. Garlic and horseradish seem to have similar effects.