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My DD2 is still breastfed very regularly. And I have yet to have AF return or any igns of ovulation. I am trying to explore options on trying to start ovulating, before tinkering with my breastfeeding at all. One website I stumbled across suggested Vitex may be of use to kickstart ovulation.
Does anyone have any info on this?
Or more importantly, does anyone know if it is safe (for my DD2) to take Vitex whilst breastfeeding?
From LactMED http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT
Rodney Whyte at Monash can help with any questions on meds and pregnancy/breastfeeding.:
Chasteberry
CASRN: 91722-47-3
For other data, click on the Table of Contents
Drug Levels and Effects:
Summary of Use during Lactation:
Chasteberry (Vitex agnus-castus) is the fruit (berries) from the chaste tree. The berries contain essential oils (e.g., limonene, cineole, sabinene), iridoid glycosides (e.g., agnoside, aucubin), diterpines (e.g., vitexilactone, rotundifuran), and flavonoids (e.g., apigenin, castican, orientin, isovitexin). Some constituents, possibly the diterpene clerodadienols, bind to dopamine D2 receptors in the pituitary.[1] In low doses, chasteberry increases serum prolactin. Chasteberry is often used for irregularities of the menstrual cycle, infertility, premenstrual complaints, and cyclical breast pain.[2][3] It is also a purported galactagogue;[4][5][6] however, no scientifically valid clinical trials support this use. In fact, some evidence indicates that high doses of chasteberry decrease serum prolactin and might decrease lactation. Galactagogues should never replace evaluation and counseling on modifiable factors that affect milk production.[7]
No data exist on the safety and efficacy of chasteberry in nursing mothers or infants. In general, chasteberry is well tolerated. The most frequent adverse events are nausea, headache, gastrointestinal disturbances, menstrual disorders, acne, pruritus, and erythematous rash; however, all are mild and reversible.[8] Because of the lack of safety data and the possibility of lactation suppression, chasteberry should be avoided during lactation.[9]
Dietary supplements do not require extensive pre-marketing approval from the US Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to prove the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does not certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information about dietary supplements is available elsewhere on the LactMed Web site.
Drug Levels:
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants:
Relevant published information was not found as of the revision date.
Possible Effects on Lactation:
In an old uncontrolled, nonblinded case series, Agnus castus oligoplex (Madaus [Germany]) was used to increase lactation. One hundred twenty-five hospitalized postpartum mothers were given the product, which was obtained from the seed of the chaste tree, in a dosage of 30 drops 3 times a day. In cases with poor response the dose was increased to 30 and 50 drops a day. Of the 125 mothers, 100 responded and left the hospital nursing their infants. Of these, 61% nursed completely, and 39% only partially. Most of the latter were primiparous women or women who had not nursed their first child. The drug reportedly lost its effectiveness over time.[10] The methodology used in this paper does not meet current standards and cannot be considered as proof of a galactagogue effects of chasteberry.
A nonrandomized, partially blinded study compared a chasteberry preparation (Agnolyt, Madaus [Germany]) 15 drops 3 times daily to one tablet of thiamine 3 times daily in postpartum mothers. Milk production was measured by the average change in weight of infants of 353 mothers treated with chasteberry, 102 cases were treated with thiamine, and 362 untreated patients served as controls. No difference in milk production was noted until about 14 days postpartum. After that time, the mothers who received chasteberry had greater milk production than those in the other groups. The effect appeared to be greater in patients with cesarean section or complications such as fever.[11] The methodology used in this study does not meet current standards and cannot be considered as proof of a galactagogue effects of chasteberry.
A double-blind study of 52 women with hyperprolactinemia compared 20 mg daily of a chasteberry preparation (Strotan, Stroschein Pharma [Germany]) to placebo. After 3 months of therapy, the prolactin response to intravenous thyrotropin releasing hormone was reduced and menstrual irregularities were reduced in the subjects taking chasteberry.[12]
In an open study of 20 healthy males, a special Agnus castus extract (BP1095E1, equivalent to 40 mg extract of chasteberry) was studied in doses of 120 mg, 240 mg and 480 mg daily in 3 divided doses. Each subject received placebo and each of the doses for 14 days, followed by 1 drug-free week. Total prolactin secretion was measured on the last day of each study period. Following stimulation by thyrotropin releasing hormone, the 120 mg dose increased serum prolactin by an average of about 16% and the 480 mg dose decreased prolactin by an average of about 10%; the 240 mg dose was approximately neutral with respect to placebo.[13]
A randomized study compared chasteberry extract 40 mg daily (Agnucaston, Biomeks [Germany]) to bromocriptine 2.5 mg twice daily in 2 groups of 40 women. One group had mild hyperprolactinemia and the other had cyclic mastalgia. After 3 months of treatment, serum prolactin on day 3 to 5 of the menstrual cycle decreased by an average of 44% to 47% in all groups. No statistical difference was found between the 2 treatments in their prolactin-lowering effect.[14]
An 18-year old woman with amenorrhea, galactorrhea, and an elevated serum prolactin caused by a microprolactinoma began taking 15 drops of a chasteberry preparation containing 9 grams of chasteberry tincture per 100 grams of solution (Agnolyt, Madaus [Germany]) each morning. After 3 months her menstrual cycle had normalized, galactorrhea had ceased, and serum prolactin had decreased by 27% (although still elevated).[15]