Clexane use in Pregnancy

Hi All,
I am after more information regarding the use of Clexane in pregnancy. I am terrified of injecting myself, but will do anything to get a good outcome this time. My specialists are recommending it's use from sometime between 12 weeks and 16 weeks. At this stage, I fall into the too hard category as they can't diagnose what disorder I have. I test negative to Protien disorders, lupus, phospholipids, Factor V etc, but I have an awful history.
Pregnany history so far:
Developed severe pre-eclampsia at 24 weeks in 2001, delivered (by C section) of a little girl (Emily) who was not given 24hours to live. Emily lived for 6 days. I recovered well.
Fell pregnant 2002, high BP straight away, put on labetelol and then aspirin at 12 weeks. Delivered by C section a beaut little boy Brock who will be three next week.
Had a miscarriage at 7 weeks in 2004.
Fell pregnant again, no high BP this time, just put on aspirin at 12 weeks. All going well till 21 weeks, a clot the size of my hand appeared, rush to hospital and two days later, (by induction) delivered stillborn son (Harry).
Pregnant again, nearly 12 weeks, no high BP at this stage. Do not know what I will do if I lose another child.
You help and support is appreciated

Hi CharlieRae,

I just wanted to let you know that I am thinking about you and I hope and [-o< that everything will work out fine for you and bubby this time round.

I know nothing about Clexane so i cant help there, just wanted to give you my support and well wishes.

take care
xxoo

Hi CharlieRae,

Welcome to BB.

I am so sorry to hear about your losses. Feel free to pop into the Pregnancy after Miscarriage/Loss Forum where you will receive lots of support and understanding.

In the meantime, you may find these threads useful:

https://www.bellybelly.com.au/forums...hlight=clexane

https://www.bellybelly.com.au/forums...hlight=clexane

https://www.bellybelly.com.au/forums...hlight=clexane

Pregnant women are more prone to clotting disorders than non-pregnant women. Should they have a certain genetic makeup that further increases clotting problems, these women become even more at risk for clotting disorders and miscarriage. The fact that some pregnant women take Clexane does NOT indicate they DO have this disorder, and I have included this for your information only.
Clexane is not expected to increase the risk of developmental
abnormalities.
Clexane does not cross the placenta, based on human and
animal studies, and shows no evidence of teratogenic effects or
fetotoxicity.
Be sure the baby’s pediatrician doctor and midwife is aware that you are on Clexane during pregnancy, so the baby can be properly assessed
at birth.
Clexane also increases the chance of bleeding so if you notice enything like nose bleeds, blood when you cough, bleeding when you go to the toilet, or even a bruise that you dont know how you got it, it is importand that you soo a doctor.

If you need any more info I am happy to help

Alan (Midwife)

Hi Charlierae,
I am sorry to hear of the loss of your precious children :hug:

I am taking clexane inj daily to help balance out my rhuematoid arthritis as i can't be on my meds whilst pg(my rhuematoligist also mentioned lupus at the start of my treatment but he lent more towards the rh. arthritis with my signs and symptoms but my bloods still don't come back conclusivly for rh. arthritis alone ](*,) ). Also from what i understand each condition can have varying reactions/results from the clexane so they will monitor you closely i would say. I get my DH to do my inj as i am needle phobic and even just the wait of a few seconds while i wait for him to do it raises my heart rate and i get anxious.

I think clexane is one of those things that is a play it by ear thing. I was originally going to be on it for a short time along with asprin daily(from transfer until 12 weeks but my OB preferred it if i stay on it as it is to tricky to predict what may/maynot happen with it not being in my system, she figured it was safer to continue taking it to help me and bubs. I will now be taking it until about 36 weeks and then be induced around 38 weeks. They do this so that all of it is out of your body to prevent excess bleeding during birth and after.

I too had pre eclampsia with my DS and had him at 37 weeks (hospitalised from 35 weeks on and off) but this time my BP is still stable ahowever i am yet to have a urine test- i think that will be at next OB visit.

I can not imagine the fear and pain you have had previously and may currently be experiencing.
I hope your little bundle hangs in there and can bring some joy to your family. My :crossfingers: for you and i [-o< this ones a winner.

Take care and good luck with the clexane. The only thing i can suggest is alternate the side of your belly you inject as you tend to get bruised and little pockets under them of scar tissue from repeatedly injecting .I have also found the closer to my belly button or out to my hip the more it hurts. I have just worked out i should only have 91 injections to go. :cheer: YIPPEEEEE

Take care and if you have any other q's i will do my best to answer them.

Hi CharlieRae,

I had Fragmin (another Low Molecular Weight Heparin) injections throughout my first pregnancy and for about seven weeks post delivery and I am starting them again tomorrow for pregnancy no 2. I am also taking Aspirin until about 36 weeks. I have Antiphospholipid Syndrome.

It is very hard when the Dr's tell you not to get excited about the pregnancy because the outcome is uncertain. It must be frustrating not having a diagnosis for your recurrent pregnancy loss and this must further compound your anxiety.

Are you seeing an OB who specialises in high risk pregnancy? I now try to avoid searching for information about my condition and the side effects of the medications I take and leave it in the hands of my specialists.

About the injecting itself, the first needle is definitely the worst. After the first one it becomes second nature. Each day I watch the sharps container filling and know that hopefully I am one step closer to delivery of a healthy baby.

I will be thinking about you as I inject myself each morning and hoping for the best for you.

Take Care

Hi CharlieRay

I have just started having 40mg clexane injections daily as well as half an asprin daily. After doing almost 12months of research into what other mothers have done to get a healthy child it seems that the injections do work. They really do leave a ripper bruise!!
Good luck
Sarah

Hi Sarah

To help reduce the bruising put some pressure on the injection site with your finger for about 1-2 minutes after you inject

Thanks for the tip Alan, I'll definatly give it a try!

Hi charlierae
I understand completely where you are coming from, and I understand how anxious and stressful a pregnancy is following the loss of children. I have lost 2 babies (19weeks & 23 weeks) and am currently pregnant, 11 weeks. My OB has prescribed clexane to start from 12 weeks to take up until 36 weeks (hoping we get that far!!). As with you, no-one has found a reason as to why I am losing my babies.
I hope all is going well for you
hayley