Help devastated...they cancelled my cycle????

Hi everyone,
Any advice would be great i have so many questions here goes....

On first IUI Puregon 75units (PCOS)

CD7 = BT + U/S ...
Estrogen low
lining 4mm
R ovary = 17 follicles largest 9mm
L ovary = 13 follicles largest 9mm

CD11 = BT + U/S... (yesterday)
lining 8mm
R ovary 22 follices largest 12mm
Lovary 10 follicles largest 12mm +15mm
Didn't get BT results til today....

Phone call received from FS nurse at 1000am today saying "we are going to have to cancel your cycle" Grrrrrr....... Your estrogen levels have dropped even lower than CD7 so the cycle won't work.....Please see your specialist (got an appt wed)

I don't really understand..... I'm so upset :cryinglaugh::cryinglaugh:...I really pinned all my hopes on this cycle and reallly feel like giving up for a while.....

Anyone of you that are more experienced with IUI or IVF ....do you have any answers or advice?

xxBella

Bella
I am so sorry hun...Wednesday must feel like a lifetime to wait for answers. My first IUI was cancelled because I had too many follicles and that was on the lowest dose...I'm sorry I don't know the answers to your questions...but I just wanted you to know that your not alone and before long you will have a heap of posts from girls who do know the answers ...and before you know it Wednesday will be here...hang in there xxx

were you on synarel or lucrin to start out with, or did you just go straight into the puregon shots??

i had my first two attempts at IUI canelled as the synarel was stopping my body responding properly to the puregon. eventually we changed the type of cycle (i don't use syneral now) and got the required response.

it's heartbreaking when you build yourself up this much to go through a cycle, only to have it stolen away when you don't respond as expected. the first cycle (or two) are experimental to see how your body responds and as much as you want to give up (i've been there many many times), you have to look at this as one type of cycle eliminated, and move forward to the next cycle

allow yourself time to be angry, sad, grieve the opportunity you've missed. then go back to your specialist and don't walk out of his rooms until he offers you a new plan of attack. you've tried plan A, time to try plan B - and you're well within your rights to ask why he thinks plan B will be more successful than plan A!!

my FS has named me his "problem child" - primarily because my PCOS is so severe so my body doesn't respond as he should, but also because i'm not a push over - i don't just accept what he says and do it, i ask why, i ask how this will improve my chances, and i won't let him fob me off! the journey you're going through now is probably one of the hardest of your life. so many unknowns, so much stress, so many hopes and expectations that you have no control over. but you have an amazing amount of support on BB, and those of us that have gone before you to answer your questions!

thinking of you

BG

Thanks guys....

BG - no i wasn't on syneral or anything else i just started the puregon on CD2 after 3 failed cycles of clomid....I do feel like no ones explaining anything to us...I think you may have seen my same specialist (if i remember correctly from on of my first posts? correct me if i'm wrong!) Mac talbot? I have heard so many good things but i'm now wondering if i should seek a second opinion???
What exactly does low estrogen mean? Might i still ovulate naturally this cycle and therefore should BD? I have been told to stop all injections now.

Thanks again for all the advice i don't know what i would do without BB!

xxBella

if your estrogen is low, i'm not sure if you'll actually get to ovulation - you may find that the follies reabsorb without actually maturing enough if you've not been triggered. i'd say if you want to BD for YOU then do it, but don't do it with the notion of getting pg as it's highly unlikely you'll ovulate. you might find that Mac puts you on additional meds to help with estrogen levels next time (maybe HRT as it's an estrogen supplement) or a higher dose of puregon but using a step up (start low, increase) or step down (start high, decrease) dosage of puregon. it's not easy to find the way your body will respond properly. i'm not sure exactly what he'll do as your circumstances are different to mine. it took him four cycles to get it right with me with IUI, so i more than understand how frustrating it can be for you!

go into your appointment with him prepared to not just take what he says. as i mentioned before, ask the questions you need to ask to clarify things in your own mind before you walk out. you're paying him to help you - he needs to actually be there to help! last week i went in, sat down, and wouldn't even think to stand up until he'd answered everything i asked. including "so, what else can WE do to help this along. you do this all the time - we don't - so you tell me what else i can do apart from jabbing drugs into me, to help this along!"

i think Mac is a good doctor, but he's one who will write you up a plan and send you on your way if you don't pull him up and ask your questions. he's been at this a long time, and knows what he's doing, but forgets that most of his patients DON'T and need not only the science side of it, they need the compassion when things go wrong, and the explanation of WHY.

so sorry, don't have any answers but i am sure the fs will know a bit more for next time? good luck

Bella, Had to reply to you as i have been through almost exact same thing.
After 2 m/c's on clomid, i was changed to puregon/IUI. My first cylcle went like clockwork and resulted in my DS. Late last yr, we decided to try for no#2. Did exact same cycle dose etc but was a total disaster. First did not respond well to puregon so dose increased. then got 6 mature follies but E2 was very low (same as you). Cycle was cancelled although i was told to trigger just to release eggs. We DTD anyway but no chance of pg with E2 that low.
Very low E2 can mean there is not enough natural LH in your body. FSH ( puregon ) stimulates the follicles to develop but reasonable levels of natural LH are required to stimulate the follicle lining cells to produce oestrogen. The good news is, all it took was the addition of low dose pregnyl (100iu) every second day. Pregnyl is used to replicate the LH surge at high doses, but at low doses will act just to help produce E2.
My subsquent cycles (sadly, there has been many!) have all had good oestrogen levels with the pregnyl. Only bad news is that you'll have more injections to give.
Hope your situation is the same and this works for you too!

Bella,
I cant offer any words of wisdom, but :hug:!

I know how deflating and upsetting it is when things dont go as planned, and despite all best intentions, we always put so much hope in a cycle or treatment, so it is so hard when things go wrong.

Hope that you get some good answers from your FS, and a positive plan forward :crossfingers: and :goodluck:.
FG