Now PVC2 has also been found in Rotavirus Vaccine

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WHITEHOUSE STATION, N.J., October 28, 2010 - At today's U.S. Centers for Disease Control and Prevention's (CDC's) Advisory Committee on Immunization Practices (ACIP) meeting, Merck provided an update of its investigation and analysis of porcine circovirus 1 (PCV1) DNA fragments and porcine circovirus 2 (PCV2) DNA fragments in ROTATEQ® (Rotavirus Vaccine, Live, Oral, Pentavalent). In Merck's final test results, infectious PCV was not detected in ROTATEQ or in the starting materials used to make ROTATEQ. In addition, PCV1 DNA fragments were below the limit of detection, and PCV2 DNA fragments -- pieces of PCV2 and not the intact virus itself -- were at low levels in ROTATEQ.

In Merck's investigation, trypsin, the only porcine-derived raw material directly used in the manufacture of ROTATEQ, was confirmed as the source of PCV2 DNA fragments in ROTATEQ. Trypsin is an enzyme used in the manufacturing process for cell growth and rotavirus production.

There is information on PCV DNA in the Description section of the United States Prescribing Information for ROTATEQ. Specifically, the language in the section is as follows: "In the manufacturing process for ROTATEQ, a porcine-derived material is used. DNA from porcine circoviruses (PCV) 1 and 2 has been detected in ROTATEQ. PCV-1 and PCV-2 are not known to cause disease in humans."

According to the U.S. Food and Drug Administration (FDA) and other regulatory agencies around the world, there is no evidence that PCV1 or PCV2 poses a safety risk in humans, and neither is known to cause infection or illness in humans.

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Merck News Item

In other words, they have no intention of removing the vaccine from the market, and are quite happy to continue to vaccinate children with it because it causes no KNOWN (caveat - at this time) disease in humans. How about the KNOWN disease it causes in pigs?

In pigs - Porcine circovirus type 2 (PCV2) is considered by most to be the etiologic agent of postweaning multisystemic wasting syndrome (PMWS) (aka pig AIDS), but it is also found in association with numerous other conditions. These conditions include porcine dermatitis and nephropathy syndrome (PDNS), porcine respiratory disease complex (PRDC) (aka pig pneumonia and asthma), congenital tremors (CT) type AII (aka pig Parkinson's), reproductive failure and enteritis.

Experimental Reproduction of Severe Disease in CD/CD Pigs Concurrently Infected with Type 2 Porcine Circovirus and Porcine Reproductive and Respiratory Syndrome Virus

Awesome! :wall:

This vaccine is all over our radios over here at the moment, they wanna pay people to test it :o

:wall: It's just insane! Thanks so much for posting.

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Merck News Item

In other words, they have no intention of removing the vaccine from the market, and are quite happy to continue to vaccinate children with it because it causes no KNOWN (caveat - at this time) disease in humans. How about the KNOWN disease it causes in pigs?

In pigs - Porcine circovirus type 2 (PCV2) is considered by most to be the etiologic agent of postweaning multisystemic wasting syndrome (PMWS) (aka pig AIDS), but it is also found in association with numerous other conditions. These conditions include porcine dermatitis and nephropathy syndrome (PDNS), porcine respiratory disease complex (PRDC) (aka pig pneumonia and asthma), congenital tremors (CT) type AII (aka pig Parkinson's), reproductive failure and enteritis.

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In the interests of being contrary.... ;)

PVC2 has never been known to cause disease in humans and it is commonly found in humans. The news report said that fragments had been found in very small amounts. Fragments, not the whole virus, not the active virus and not even in significant amounts (it takes a reasonable amount of a virus to infect a person).

Not that I'm saying its right, just putting things into perspective.

The rather nasty experiment linked by Yeddi is mostly about PRRSV, and the PVC2 pigs fared only slightly worse than the controls.

You're kidding, right?

I'd like to back up RockinSAHD
only full virus is infectious, fragments of DNA are absolutely meaningless. It's like saying "human flesh was found in the milk" when what you detected was half a skin cell! (actually, half a skin cell has the potential to be far more dangerous to health than a DNA fragment!)
Tests are so sensitive and when reported and interpreted in the wrong way can amount to misinformation.
And of course you wouldn't do it on purpose without research, but the only possible health outcome of having virus fragments in a VACCINE is that you would accidentally boost someone's immunity to that virus!

And what research are you basing this on? I'd like to see it. :D

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You're kidding, right?

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No, sorry I'm not. The study you linked showed the pigs only slightly worse off than the controls, these were newborn piglets who were injected with a large amount of the (whole) virus and showed none of the nasty symptoms you quoted and its a pig-disease!

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"In pigs - Porcine circovirus type 2 (PCV2) is considered by most to be the etiologic agent of postweaning multisystemic wasting syndrome (PMWS) (aka pig AIDS), but it is also found in association with numerous other conditions. These conditions include porcine dermatitis and nephropathy syndrome (PDNS), porcine respiratory disease complex (PRDC) (aka pig pneumonia and asthma), congenital tremors (CT) type AII (aka pig Parkinson's), reproductive failure and enteritis."

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Okay, so apparently a vaccines contaminated with foreign DNA particles from deadly animal viruses is perfectly fine and justifiable? Read that sentence again and tell me that doesn't sound insane.

Regardless, people have the right to know these things, and have ALL their concerns properly investigated and considered, not fobbed off as not being a problem. There would be a lot of people out there that would think this is a problem. I am not interested in making this another Anti/Pro vaccine argument thread, or delving into excuses for this inexcusable contamination.

Imagine how the Muslim families feel about having their child exposed to a pig virus. Repulsed. Violated. Permanently unclean.

Jewish communities wouldn't be fans either.

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Okay, so apparently a vaccines contaminated with foreign DNA particles from deadly animal viruses is perfectly fine and justifiable? Read that sentence again and tell me that doesn't sound insane.

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Well, try this one: Vaccine contaminated with very small amounts of DNA fragments from a benign virus that infects only pigs.... Justifiable, no, but cause for further testing and research.

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Imagine how the Muslim families feel about having their child exposed to a pig virus. Repulsed. Violated. Permanently unclean.

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That's actually a really interesting though. I wonder what Mohammed would've said about viruses? They aren't pig products but independent living organisms but it's interesting.

What about a fragment of pig DNA in some GE wheat? I'm sure that would give The Prophet reason to ponder.

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Justifiable, no, but cause for further testing and research.

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...Research that they are very unlikely to do because they've already claimed it as safe, and unless something makes them (like people not taking it up, or suddenly people start getting very sick and they can't somehow find a way to refute it as just being just coincidence) they most probably wont ever do any.

Have you ever watched Fight Club?

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A new car built by my company leaves somewhere traveling at 60 mph. The rear differential locks up. The car crashes and burns with everyone trapped inside. Now, should we initiate a recall? Take the number of vehicles in the field, A, multiply by the probable rate of failure, B, multiply by the average out-of-court settlement, C. A times B times C equals X. If X is less than the cost of a recall, we don't do one.

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Similar sentiment really...

ooohh i love a Yeddi vs RSAHD thread. i learn heaps. :) u guys could seriously talk for hours over a cuppa. (although the cuppa might go cold);)

*Giggle* I actually think one of us would end up wearing the coffee. :ROFL:

TBH on other topics, we'd most probably get along really well, but on this topic, we will always be likely to butt heads.

I'd like to be a fly on the wall during this coffee date! Hehe!

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I'd like to be a fly on the wall during this coffee date! Hehe!

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i will stand next to you but we will need a shield of some sort to repel the china....:rofl:

seriously though, its great that u guys are on opposite end of the spectrum. theres no one person rampaging through the forum with a particular opinion on a topic, u meet halfway and are respectful to each other. and you are both giving us plenty to think about :) thanks.