what was your dosage?

hey

just wondering what dosage of puregon you were or are on for your cycle??

also how many follies did you end up getting from that dosage?
also how many scans did you have when you started injections?

the cycle i just had which was cancelled i was on

* 100 iu puregon = 1 scan ( day 10)= 2 follies

my next cycle they are putting me on 150iu and hope that i get a better response.

i know each person responds differently but it would be interesting to see how people went with different size dosages.

thanks

on 100 i didn't respond at all
150 - one dominant follie
175 - one dominant follie
200 - between one and three dominant follies - and up to 30 large follies so high OHSS risk
300 - 59 dominant follies, 22 eggs, 11 mature, five fertilised

umm us ivf # 1 =125 of gonal f =2eggs no fert no transfer
ivf # 2 =225 of gonal f=9 eggs 2 embies bfn
ivf # 3 =225 of gonal f=12 eggs 7 fert a bfp and 5 frozen bubs left
i cant really remember how many follies but hun soz

OK, straining my brain to remember this now but pretty sure for us we started on 125 gonal f and I had no response so FS didn't muck around, upped it to 300. I had only 8 dominant follies on our last scan before epu but had 14 eggs collected, 100% fertilized and we had 11 embies, one transferred, 10 frosties left.

That was all from one ovary, my left has been partially removed and didn't produce any mature eggs.

Hi,

1st IVF = 200 - 22 eggs collected, 11 fertilised, 4 survived (day 3), 2 ET all BFN, 1 died during thawing.
2nd IVF = 175 - but my level was very high at BT and FS reduced it to 75 for the last couple of days. Had ~10 follies and some smaller ones. 12 eggs collected, 11 fertilised. All grew to day 5. 1 fresh transferred (early m/c), freeze 5 (the other five they chuck). 1 FET (BFP).

Kahlan

ok, had to look for my diary from last year lol!
I was started on 150 puregon, first injection on a Friday morning.

First scan on the 6th day (following Wednesday) , wasn't allowed to do injection until after the scan. Stayed on 150.
Another scan 2 days later on Friday. No injection that day.
Had 14 follies, with a 15th that was on the small side. 15 eggs collected and was told they were a little immature. 11 fertilised, 2 days later for transfer, told that 1 had stopped growing, they didn't know why, another hadn't formed properly or something to that effect.
1 put back, 8 snowbubs :)

Nic

started on 150IU on day 4 (late start!)
went up to 200IU on about day 8 after first blood test
only 1 dominant follicle (4 small ones) and they talked about cancelling the cycle, but then we decided to focus on growing the group of smaller follicles
scan/BT ... scan/BT ... scan/BT etc. until day 14 scan, 7-9 follicles
EPU day 16 - they found 17 eggs (don't know where!!)
1 x blast transfer(BFP); 8 blast frosties in reserve

After seriously considering cancelling this cycle early on, I am thankful every day that we persevered because it has delivered our long awaited BFP! :D

Mine are complicated... Unfortunately, I have tables summarising my E2 levels, but not my puregon dosage.

Cycle 1 - Started on 150IU for 5 days, no response, did 4 days at 300IU and got too much response and the dose was reduced over the next 4 days. I had no puregon just lucrin the night before my trigger.

We ended up with 26 eggs, 21 were mature, 15 fertilised, 4 made it to blast and were frozen. No fresh transfer, and only 2 of those were able to be used in FETs.

Cycle 2 - Started at 300IU for 2 days, 200 IU for 2 days, 150IU for the next day and then I was in for a blood test. Too much response again so we spent the next 4 days gradually reducing the dosage to nothing. I had no puregon, just lucrin for 2 nights before my trigger and had about 3 doses or orgalutran towards the end trying to keep levels down.

We ended up with 32 eggs, 30 were mature, 20 fertilised, 7 made it to blast and were frozen. No fresh transfer again, and once again we only got to use 2 for FETs.

And that's why you don't want to get OHSS!

Cycle 3 - Started at 200IU for 5 days, was reduced a bit slower and my final dosage was about 50IU the night before trigger.

We got 20 eggs, 12 were mature, 3 fertilised... we transferred at day 3 and got a BFP, the other 2 were frozen.

As I said, complex, complicated and a great demonstration of what you DON'T want to happen! On the third cycle they took me to EPU as soon as I had *some* mature follies, rather than having *most* of them mature. It was all part of the avoiding OHSS plan. I was pretty annoyed at the time, but it seems to have been what my body needed, and I suspect that even though we got very few embryos, they were much better quality eggs this time around.

BW

Ist IVF - 300 iu Puregon daily
scan at day 9 - 17 follies
scan at pick up - 19 follies
EPU - 11 eggs
5 fertilised - 2 embies t/fered - 4 & 5 cell
none suitable for freezing

mumtochloe

reading you dosage really surprises me and this whole ivf journey, and how each clinic works differently -

you were on 100 in your first cycle, I was on 300, now I am on 75 on my own, trying naturally - its only 25 iu more, maybe your clinic is more conservative ?

wlb - a lot of it comes down to how you respond. if you have stubborn ovaries (like me) you need high dose to get a minimal response. anything less than 150 i get nothing, even on an IUI cycle aiming for one or two eggs.

M2C has a history of OHSS on IUI's so they would be conservative to stop that happening...

BG - OIC

What is a IUI - ?

Having PCOS complicates everything. For me, the dosage needs to be high enough to get a response, but there's a VERY fine line between no response and too much response with me. It's always easier to stimulate the ovaries of woman without PCOS as things can be a little more predictable. Some clinics take the cautious approach while others... well... they tend to go to egg collection and freeze all rather than cancel, but this can leave you very sick - I was in hospital for a week after my second EPU.

IUI is intra-uterine insemination.

BW

intrauterine insemination is when you are stimmed to get one or two decent follicles, then triggered (like IVF) but you Ovulate naturally, and your DP's sperm are placed in your uterus via catheter so that they're waiting for the egg. our current pg is from an IUI cycle

Oh BG - Thank you

I should have done that this cycle - Im going to ring the clinic and talk to them - OMG !! This is driving me insane - I keep changing my mind ..

Wow it amazing to see how everyone had different size dosages and different reponses
its so interesting, thank you everyone for sharing:D

ok so i have been doing some thinking and would like to run it past you and let me know what you think??

so we all know that my first cycle was cancelled and i was on 100iu puregon, i had 1 scan which was on day 10 of injecting.

this is what i was thinking about asking fs, if your body chooses the follies within the first few days of injecting, then is there any chance we could try maybe 175/200 iu for the first few days and in them days we will do as many bt's and ultrasounds as he wants and once we can see that we are getting a response, we can lower the dose so we can try and avoid overstimulating.

do you think that this is ok to ask??

i am so desperate to avoid having another cycle cancelled that i am willing to try anything.

ok let me know what you think
thanks in advance

wouldloveabubba forgot to ask, how did you get on with your fs about doing iui??

let us know how you got on ok!

M2C, I asked my FS once if it was worth doing earlier blood tests - and he said that there's no point before day 5 of injections. Something about it taking time to get E2 levels up and we won't see it before then. I suspect it may be a similar thing with scans - there's not much point scanning earlier as (particularly if you have polycystic ovaries) it would be hard to tell what's a follicle growing/responding and what's not. It may be worth asking about the step down type cycle that I did - start high to get a response, but keep the dosage reducing to try to avoid an over-response.

I hope that makes sense... I'm not sure I'm expressing myself clearly today. :doh:

BW

ooooohhhhhh ok;) thanks so much for that bw

so i will see if i can do what you done with your cycle, start big and slow it down once we get a response.

at least then we know we are getting something rather then nothing like what just happend.

so does this type of cycle have a name or do i just explain it to him?? lol

M2C - My last one in Jan I was on 150iu of puregon for 9 days and then the trigger. I had 12 follies and 12 eggs with 10 fertilising. We lost many the next day ended up with 3 great ones...

This cycle I am on the same dosage hoping for similar egg numbers. Hopefully we won't loose as many this time - DH has been on Menevit it will be interesting to look at numbers (as our issue is swimmers!)

Goodluck with your next cycle hun..
Rach xxx

thanks for that rach81

wow look at you not long to go now till epu:dance:
you responded well to 150iu last time, i bet you will do great this time round aswell
i wish you loads of luck and will be lurking around to see how it all goes for you hun:D

I believe it is referred to as a step down cycle. However, it didn't turn out too good for me - the one where we did it the traditional way, I landed in hospital for a week after EPU and was off work for a month...

The one cycle where we avoided OHSS was the one where we started at 200IU and dropped slower, keeping a VERY careful eye on things - daily blood tests from day 5, which got VERY draining. But what I think the key difference was - following an extremely strict low-carb, low-GI diet for the duration of the cycle, from about a week or so before we even started down reging. I had one blip in my E2 levels towards the end of the stim phase, and it matched exactly with the day I thought "stuff it!" and had a burger and chips for lunch. Considering I was on daily blood tests at that point in time, it was pretty obvious.

BW

Thanks sooooooo much for all of this BW:D
you are such a great help not only to me but to everyone on here
you are a kind person with a caring soul;)
thanks hun xxx

Sorry just a quick question i know this is off the topic of this thread but feel more comfortable asking it in here then in the tww thread.

I had my trigger shot tuesday morning ( 5000iu pregnyl) just wondering when do you think i will ovulate?? would it be yesterday, today, tomorrow?? just that i have NO signs at all of O coming?? i have super sore nipples today but other then that nothing?? how do i know if i am going to ovulate?? i am not sore and i dont have ewcm?? would i still get all of my usual signs that O is coming even though i have had pregnyl??

this was my problem with all of my iui's i had no signs of o'ing with pregnyl but yet clomid on its on every now and then i would get ewcm so i knew something was happening.

so what do i do?? do i just trust and hope that the pregnyl ( which is the biggest dose i have had, usually 1500iu) is doing or has done its job and i have o'ed or do i just keep checking and see if i get any signs?? and if i dont O what happends to the 2 follies where do they go?? lol do they sit there or do they disappear or do they turn into cysts?? probably silly question sorry but had to ask

They time egg collections for IVF at 36-38 hours - just before ovulation happens by itself. So it will definitely be more than 36 hours after the trigger, and I think from a bit of similar research conducted with BG a while ago, no more than 40 hours after trigger.

I'm not sure what happens to follies if you don't ovulate - I guess they could become cysts, or they could just get reabsorbed.

And M2C - it's no problem at all! I'm a teacher at heart (and by profession!) and I just love educating people about this stuff... just be thankful I'm taking a little break from the maths at the moment! :lol:

BW

I was on 100iu for 10 days. 20 follicles were seen on my last scan, 12 eggs were collected, 8 fertilised, 1 transferred and 7 frozen at 3 day x 4 cells. Ended with a BFN. Did a FET next, lost one in the thaw, defrosted another one that divided to 6 cells by transfer and got our BFP!

I have PCOS also, so my FS always errs on the side of caution with lower doses with me and then lifts them if need be. I went through 6 months of OI on Puregon prior to IVF, so FS had a pretty good idea of how I reacted to the drugs, although with PCOS, your ovaries have a mind of their own!

All the best of luck.

Janie xxx