Domperidone has properties similar to metoclopramide and is used for gastrointestinal conditions such as nausea and vomiting, and gastro-oesophageal reflux. It is also increases prolactin levels. It causes fewer side effects than metoclopramide.
One study found daily milk production increased and at one month all women in the treatment group were breastfeeding adequately, while only two of the placebo group had sufficient milk. There were similar findings in a group of women treated for low milk supply two weeks postpartum.
SUMMARY
Domperidone given for four to ten days has been shown to increase prolactin levels and milk supply. There appear to be fewer side effects in the mother with this drug compared to metoclopramide. While it appears in breastmilk, there is no indication that it affects the infant in the doses used.
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