Hyperemisis with both pregnancies here.

Totally unmedicated first time...lost 12kg, couldn't eat, In hospital heaps for dehydration, the usual. Puked 10 times in one morning when I was 36 weeks and thought I was going to die, it was so violent.

This time...the ONLY thing that kept me sane was just biting the bullet and spending the required $150 a week on Zofran. It wouldn't take away the sick feeling but it did stop the vomiting.

Note about Zofran: If you start taking it very early in your pregnancy it has apparently been shown to actually reduce the time that your hyperemisis lasts (helps stop it for good). I'm 25ish weeks now and not puking every day, just a few times a week, so it's worked.