I haven't been technically diagnoised with endo yet but I rarely wore them for the first few days as I found they exaggerated the already hideous cramps. And ditto with the family history, all the women in my family have had bad periods with nausea, vomitting and diahorrea. My only salvation is that they also have early menopause, otherwise I have another 25 yrs of this to look forward to as we aren't planning on having any more children.