I went to the UK with a 16month old, she was great on the plane, although we did a stop over in Malaysia both ways so didn't have a flight longer than 8hrs. Breastfeeding is a saviour when flying and everyone complimented her on her behaviour. We booked seats at the front with the extra leg room and she sat on the floor and played a lot. We also had my iPad with Peppa pig episodes downloaded.
It's up to you, how helpful is your hubby? Mine was pretty useless on the plane but good in the airports etc.
not sure if I'd do it pregnant, just for the tiredness factor. In regards to the sleeping with time zones, I found she adjusted really well going over, worse when we came home but didn't matter then. They are usually so excited to be on a plane and see new things that they wear themselves out.