Hello all,

we had what was meant to be our last IVF attempt (for bub #2) last month (the 8th cycle in past 2 years), but the cycle was cancelled before transfer after 3 eggs collected (1 mature didn't fertilise, other 2 immature -> delayed ICSI, didn't progress well).

I have a bit of a dilemma facing me now that my DH and I agreed to give it "one last shot" as we feel we didn't get a proper go with nothing to transfer.

In the clinic we were treated when living in Adelaide last year, their maximum FSH dose given (Puregon/Gonal-F) was 300 iu. They agreed to go up to 325 iu as this what my Perth clinic had me on just before I moved over. I only ever got 1 or 2 follicles from that dose. My advise from the Adelaide doctors were that studies showed that any dose over 300 iu made little or no difference in folllicle growth, and there are some opinions that overdosing the FSH can actually be detrimental to the eggs.

HOWEVER, now that I'm back in Perth, my clinic want me on 600 iu, the maximum dose at this particular clinic. Now, I was skeptical, but I did two 600 iu cycles: 1 which was cancelled due to development of a cyst, and the second which again only resulted in 1 mature egg (the last cycle, that was cancelled due to no embryo).

They want me to go on 600 again for my next cycle, after a 6 week bout on the pill.

I'm now concerned that I should just stick with 300 as my previous clinic recommended, as I'm worried that 600 would possibly worsen my chances. I'm considering not telling my doctors this as I don't want to feel pressured to up my dose after a mid-luteal blood test (which happened last time).

Thanks if you've kept with me so far on this very very long post... but my question is this:

Do you know what your particular clinic give as a "maximum dose" and what has been your advice on doses higher than this ?

Thanks again ... you girls/guys have been such a huge support over the past years.