IVF with PGD #4

Motherhood - IMO I think you are going along fine, our first ivf cycle is just that, the first cycle, it is trial of meds to see how our bodies respond, for an example, the satelite clinic I am at atm, has EPU , every day this week, as every woman responds differntly to the meds, ad our nurse said, please donot worry about changes to meds and timetables, our bodies will do what the want.

Best of luck hun, your epu will be hear before you know it :hug:

Loula - helo my friend, you know that they are doing cgh IN sivf now ??

ferrals - my fs said "no" to vitex too

hi to everyone

Hi ladies, im new and just wanted to say Hi and Good luck to you all.
I will be having my 2nd cycle of PGD IVF in Nov and thought i might start keeping my eye on this thread.
Jaki xx

Evening Ladies,

Well a quick update for you all. AM not feeling the best this evening.

So DH and I went in nice and early this morning for my US and BT (Had to try twice this morning as they couldnt get the first one ) with FX that we would find my little follies had done what we wanted them to do and that is grown.

Cut a long story short. Got the call from the PGD Nurse this afternoon. Because of the fore warning on Thurs about the possibility of cancelling, found it kind of tough over the past couple of days not to mention even tougher to try and keep my mind busy today. Anyway, she let me know that the US results were no real different than that on Thursday. 1 Follicle at 18mm and two at 16mm and a hole heap others well below that. The good thing I thought though was that at the US this morning, Uterus lining was 13mm!!!! So I was provided 2 options. 1, continue with my injections and go for another BT and US on Monday in the hopes that the others had had a growth spurt or 2, I trigger today and we cancel the cycle because of poor performance. Had a chat with DH and then called back with an answer. After much discussion, we decided to cancel our very first cycle (. My theory was that were there for IVF, ICSI, PGD so that means there were alot of odds that those 3 had to make it through, FOr starters, they had to be viable, then fertilise (ICSI) and then after that make it to day 5 blastie and then make it through PGD with flying colours. Deep down, I didnt really think that the follies would respond well by Monday and then we would be crossing the same path as now and making a decision then. I mean, with the big up in my dossage I was given on Thursday to today didnt really seem to make a difference to the little follies. From what I could see, maybe only one kind of responded. So called the Nurse and advised her of our decision, as heart breaking as it was.

Instructions - Trigger at any time today (I did it at 6.30pm, had no prob snapping the vials etc but man oh man did it hurt as I injected, not to mention its quite a thick solution to inject) Store all left over meds in the fridge ready for our next cycle which were going to start ASAP. Nurse will send out another pack for myself which includes the next script for Lucrin and cycle diary etc. Need to wait for AF again!!!!! Once AF arrives, call the clinic, start the OCP and off on our way again for try number 2. FX hey we have success. FS has said that at next cycle, I will be started on a higher dose of FSH to begin with.

So have decided that starting next week, am going to start Accupuncture treatments and will continue these all through the cycle. Am also going on a bigger health kick. Walking everyday etc, etc. Anyone have any experience with Accupuncture. Am hoping it helps to keep myself calm Am definately going to be positive all the time now. At least I know what to expect. Glass is half full attitude hey!!!

Thats it for me. Will definately continue to lurk around and keep up with your ladies progress but hopefully before too long, will be back in here.

Sorry for the long post, just helps to get it all out especially where I have others who know and understand what it is were going through.

FX for all in 2ww and good luck for EPU to everyone else there.

MHHIC so sorry to read your news. i sorry i dont know your reasons for needing PGD. thinking of you tonight. first cycles are always so experimental. i hope you can find reasurance in that, and that next time will will think of a plan. i havent heard of people being able to do back to back stims and have always thought you needed to wait two cycles
GL

Sorry about your cancelled cycle...
As for the Acupuncture, my friend had it and swears by it, she was lucky enough to get her BFP first cycle and transfer, i am Defo doing it myself this time round as my last cycle i had bad quality eggs.
So i say if its one more box you can check for your own piece of mind then go for it!
Jaki xx

Hey everyone :)

Hope you are all doing ok on your journeys.. mine had a bump in the road today as I got my period :( Had a pretty sad day but I know there are many who have been here so many times so feel for everyone and their paths.

Ferrals - any more news on your test or just playing waiting game now? We cracked champagne when we finally got ours (anyone would think we were preg ;)) Thinking of you :)

Jaki - Hi there and welcome to you. Where are you on your PGD road?

Hope everyone else is travelling well and remembering that the journey is an important part of your road trip

xo

Hi Onja
I had my first cycle of PGD in dec/jan. and had a pretty rough time, ended up very sick and with nothing to transfer. So we got sad, then got mad and decided to spend all our IVF money on a wedding, lol. Then we decided it was time to try again and have been saving up like mad.
So in Nov off we go again! I am doing a 'short cycle' this time to hopefully get better quality eggs. We live in central QLD and go to Sydney for our IVF so it is quite a mission!
My PGD test was generated in 12 weeks, i can't believe yours took 2 yrs!!!!!!!! It must have felt like forever!
xx

Onja, OMG i forgot to say so sorry you got your period, big hugs!
Do you have a frostie for a frozen cycle or are you back to square 1?
xx

Hi ladie's

Motherhood-so sorry to hear you had to cancel your cycle you must be heartbroken i think you made the right decision as PGD IVF is a number's game you need a fair number of egg's to start with as we all know having uneffected embie's at the end is what the goal is it sux's to think we have to go through this process and it still can go the wrong way.

Jaki80-Hi and welcome i also am looking into acupuncture before i start i will give anything a go.

Onja-I'm devo for you i was hoping it would work first go and then i would be optimistic it could work fisrt go for me and no we are still waiting i am getting real impatient now they give you a phone call and tell you almost there get our hope's up and then nothing still waiting anyway i was reading your post's in the other thread and was keeping an eye on you i hope when you start your next cycle i will be doing mine and we can be cycle buddie's.

To all my other PGD ladie's hope all is well with everyone.

Hi all,

Just want to start by saying a massive big thankyou to everyone of your for your kind words of comfort. Since the idea was put on the table last thursday till even last night laying in bed, has definately been a rough few days.

Have come home early from work today, not because of being upset but because Im ovulating at the moment after having the trigger Sat night @ 6.30pm and boy am I so uncomfortable and in a bit of pain. Thought it best to come home and rest up on the couch this arvo and tackle tomorrow, tomorrow. Pains not too bad just so uncomfortable especially when you move in certain directions!!!

Moving forward Plan of Action!!! Took my trigger on Sat evening and so now need to wait for AF to arrive!!! In the mean time the PGD Nurse at the clinic told me that she will get together another pack for myself which will have a new script for Lucrin, new script for OCP and my new cycle diary. In the mean time though, she did remind myself that when AF does arrive, be sure to give them a call so we can put the dates into the cycle diary. Then we need to go through the whole cycle again. This time however FS has told me that we will without a doubt be starting on a higher level of FSH this time.

Ferrals4 - As heartbreaking as it was to make the decision Its hard to turn the emotions off and oh so dissapointing for this to happen first go. FX that the FS learnt from this failed first cycle. I know exactly what you mean with regards to the numbers game and that very reason is why I made the decision that I made. Not knowing too much technically, I didnt think and it was easy I think to see that with the follicles we had this first cycle the odds were well and truly stacked against us. In a weird way I suppose, looking back its a little less hearache than what might of been had we continued.

I suppose also looking at it Im greatful that DH and I have the financial capability at this point in time to do another cycle straight away.

Im determined to be extremely positive this second time. No more looking back only looking forward, no more glass is half empty attitidue, glass is half full!!! Even called an Accupuncturist this morning whose details I got from an old thread on here and have my first appointment with him on Wednesday.

Best get back to resting.

Thanks for listening/reading my rants ladies. Its very much appreciated.

Hey fellow PGDeans

Well its an official BFN :( I guess there was a lot of hope (and two years of waiting) going into that transfer so... I'm pretty sad this week.

Jaki loved reading that you blew your money on a big wedding - that's awesome ;) Hope the savings are coming along ok.. whenever you are saving for something doesn't everything else come up as well!! :wall: I hope we all get pregnant before the end of the year! Thanks for your words

Ferrals hope the wait is going fast - any dates as yet? Thinking of you too :)


AFM I guess like I was saying to 'Motherhood here I come' I also kinda had this wild hope that as we did not have any infertility issues that it would just happen on the first go :rolleyes: I know wishfull thinking.. I have been having a big ponder on it and fertility isssues or no, it's still a 'foreign' thing for your body to do and I guess no one can tell how any of our bodies are going to respond to any of it.

This is the latest info i have from the scientist.

Hi Sandra

The final marker for the deletion mutation arrived today. I have just finished amplifying it to see how it works and am running it on the analyser tonight. We already have identified the fingerprint markers and I am trying the first combination now- they are amplifying while I write this email. This is the stage where we keep trying different combinations to find the most stable mix for the final test. I cannot say how many attempts this will take but I hope this part will be ready in two weeks or so- then it needs a second check but this is usually only a few days. I will keep you up to date as things progress.



I hope all is well

Best regards

Don

So more waiting god i hope they make it before my AF in oct it is due on the 10th so that's eprox 4 week's away.

I'm not feeling to optimistc right now i have been reading a lot of ivf thread's and there is a lot of disapointment a lot of cancelled cycle's and BFN and it is making me feel bloody awlful we only have one maybe two chance's before janurary to try this and now i'm thinking the worst i will never be able to give the love of my life a baby it just sux's we can have kid's to our ex's but not each other our child together was serverly abnormal i feel like a failure sorry about the me rant and sook i'm premenstral just having a bad couple of day's

Ferrals4 i know the threads in here can be so daunting, thats why it took me so long to start using this site, because every time i read the threads i'd cry and convince myself it wont happen for me.

Just try to see the threads as a place for support and venting, and remember there would be alot of ladies out there who were in our situation who aren't on here to boast their success!!

xx

Thank's jaki80 i know you are right i am just in a panic at the moment but i did get some good new's today i got my DH sperm test result's and the FS said they are excellent 120.5 million per ml and 507.65 million total motility 67% and morphology all normal so that is good i diddn't think it would be a problem as we havn't had a problem conceiveing but it help's to know his swimmer's are good quality.

Motherhood-how are you going i hope all is well.

Onja-ive been thinking bout you i hope you are planning your next cycle.

Hello to everyone else.
I'm going insane with the waiting i'm glad i will be working a lot of hour's this week.

Ferrals :hug:

Look behind you girl... cause although you might not feel it right now - you have come so far!!!

There is a lot of cancelled and negatives here but I guess we all want to rant and write more about the bad. Prob lots of people with positive results that would feel 'bad' about posting their good news. Also I did get a partial take (think they call it a 'chemical pregnancy' which I was upset about but my acupuncturist said is a good sign as it shows 'It started to happen' hoping the next time -- it will uhh get with it. I have never been pregnant before and am 36.. reckon my body was a bit in shock that it was actually happening ;)

Got a call from the receptionist at Dr Burmeister's clinic (my FS) and they are saying something about me having to wait till she comes back to start my next cycle (Oct 12th). Ahh don't these specialists know we are all thrying to do this before the year runs out :rolleyes: I am thinking of changing FS

Hope everyone is is doing ok

Sorry Jak.. was quick to want to want to support dear ferrals and didn't read yours - like minds ;) Hope things are going ok for you :)

Hey, thats cool... things are great.
Very busy in Oct so just waiting for the Nov period and away we go!
xx

Hi girl's AF here so i'm over my hormonal crisis i feel better today thank's.

Onja-you are right i should think about all the positive's having a chemical pregnancy is a good sign hope the next one stick's for the long haul and i know what you mean with the FS taking there time i rang to talk to mine and 2 day's later i get a ph call to say they are sorry for taking so long but they are swamped with people trying to get in before january to have there frostie's transfered our cycle's cost twice a much if not more and with pgd chance's of having enough uneffected embryo's you think they would speed it up a little i'm trying to push for oct so if it fail's we might make it in dec for a second go

Hey ladies...
Just a quick note to touch on what ferrals said about getting in before Jan.... i got a letter from my FS today about the changes and how it'll cost heaps more for IVF esp with PGD. Im sooooooooooo cranky!!
I dont understand alot about politics or what the gov does but it seems so me for an 'underpopulated' country who pays people baby bonuses so the population rises, which is some peoples main reason for having kids, want to make it harder for us hard working decent folk who need a helping hand!!
Any thoughts??
xx

Jaki-when all this started i emailed all the local pollie's and then emailed kevin rudd to give them a bit more info on pgd ivf patient's the way i explained it (i will give a shortened version) when we found out that abbi had some pretty servere abnormalitie's we had a lot to consider with multiple surgerie's possible life support for a period of time ,long term therapy ,permanant care and assistance with feeding respite care and a hugeeeeeeeeeeeee!!!! amount of medical cost's after our head's were filled with all this and more it was just not fair on abbi what i said to the pollie's was if we had continued the pregnancy the government would have footed the medical cost's and care for abbi's entire life and then i would have had to give up work and go onto a carers pension (more government money ) so i said what would be more cost effective to the government to help people like us have healthy babie's at a small cost to the government or to get pregnant natrually and risk having a very sick baby and then the government will have the massive cost of supporting that child and the carer's for the entire life of that child i can't understand how you can cut cost's to ivf we are a hard working tax paying couple who are trying to avoid the heartache of having a disabled child unemployed people get $5000 to have babie's if the government help's people like us in the future you will get healthy children who will eventually contribute to the community as tax paying adult's.
I could go on and on and on but i get to cranky i should have kept my email i would have attached it for you to read.

Good work with the letter!!! Im the kind of person who grumbles but doesn't complain :wall:

So sorry you had to go thru all that with your abbi, it must have been so hard. I was told years ago i could test my babies at 19weeks for my disease and have a induced birth abortion, but i think all these years later its fate that we cant fall pg and have to do the ivf anyway.

Meanwhile i also found out this morning the baby bonus is means tested!!!!!!!!!!!!
So we will not even get a small helping hand from the Gov there, what a bunch of a**.

xx

Jaki-Now we know that DH and i carry the SLO gene which they can test for with a CVS we can fall pregnant natrually and test the baby at 11 week's and terminate at 13 week's if the baby is effected but i would like to try pgd first and avoid that stress if we can i was worried about the 12 week nuchal scan with abbi before we even knew there was a problem i couldn't imagine how hard it would be if i fell pregnant now and had to wait 12 week's to know if we could keep this one or not how stressfull the government should read these thread's and see the pain and suffering we go through why should we be put through all this bull#@#t when the technology is there to avoid it and this mean's testing is a bit harsh we get the raw end of the stick because we work hard and don't sit on the dole with our hand out we miss out on the benefit's somtime's i wonder why we bother to work our arses off pay our taxes i have to stop i'm getting cranky again the whole thing s#@t's me

Im totally with you!!

Hello ladie's just checking up on you all hope everyone is well.

AFM-I'm going insane waiting i am supose to get a progress update on our probe testing this week but so far NOTHING!!!

Still nothing?? And less than a month to go, they wanna get their act together! lol.

Im just playing the waiting game, got the drugs waiting at the pharmacy, got all the cash together to pay the clinic... just gotta get thru oct and wait for Nov period..... Hope it goes quick!

xx

I couldn't wait i rang the PGD scientist he said the testing is looking good well that's not what i need to hear right now ! i asked will it be ready before my next cycle i'm due on the 11th of oct he said it should be and i should get a call in 2 week's that's what he said 2 week's ago i said that is cutting it real close that will only leave a matter of day's i said if it look's ready to go let the pgd nurses know so i can start the injection's while they finish the last lot of double checking at least i will be started
grrrrrrr!!!!!! this is nerve racking i have payed up front and have my orgalutran in the fridge and stocked up on panadole just need the fsh and trigger injection and i'm ready to go.

I would be pulling my hair out!!!!!!
How long has the test taken all up? Mine was only 12 weeks thank god, i've heard some tests take years to formulate.

Don't you hate how Doctors and scientist are all cruisy about stuff, its so annoying and it doesn't help us!!!!!!!!
LOL

xx

we had a lot of the testing done through the hospital when abbi's autopsy was done so that has helped the ivf clinic but that started back in may the ivf got abbi's DNA and our DNA in late july so about 8 week's with them and they did say 8 to 10 week's as all the hard work was already done but i am pulling my hair out! i might miss oct and be cycling with you in nov anyway better go i'm on my dinner break from work have to get back

Well i sure hope it works out for you in Oct but if not i would love to have a cycle buddy!
xx

Hey girl's very quiet in here i am still waiting patiently (NOT!) they are cutting it real close the PGD nurse told me if i feel my period comming on to ring her and she will chase the scientist down and find out how close our test is to being ready ,talk about nerve racking torture the whole medicare rebate january nightmare is looming and making everything so much worse.

OH MY GOD!!!! GOOD NEW'S
I just got a phone call from the scientist our test is finished and is being sent today for it's second check and he said stop panicing i will get the green light next week and i will definately be able to start in oct yippeeeee!!!!!!! finally after 6mth's i can actually try for a healthy baby .

:hello: Ferrals I haven't posted on this thread for a few weeks but have been quietly watching from the sidelines. Just wanted to wish you a world of good luck for your cycle in the coming weeks :goodluck:

YAY!!! Great news , now you can relax and let it all happen!

Are you doing a short cycle?

I am this time so i am taking very close notice of my body this month to try and gauge next month, i have never been able to keep very good track, lol.
And because i spot before i get a proper flow im really scared ill miss the window as the nurse said to go for the BT the first day of heavy flow. And i have to drive over two hours to get a blood test i don't want to mess it up!!

Thank's Where theres hope i will need it.

Jaki-I am doing the short cycle as i can't take the pill and i have heard many good storie's of women responding well to it i hope i do.
I have a pretty good idea of what my body is doing i am very regular 28-29 day's on the dot and i can feel when i ov but i never get any ewm so no help to me there and when AF show's it usually just start's with a light flow the first day then full on the next day but this month i started accupuncture and i am on cycle day 17 and did not feel myself ov this month so not sure if the accupuncture is the reason or not but i'm due for AF on the 11th or 12th of oct so we will see anyway i am so excited and terrified at the same time.
I do have a question for you ladie's where did you find was the best and least painfull site for your injection's.

Fingers crossed it comes right on time for you then!

As far as the injections go i was on my own there, my Hubby said no way im doing that! So that ruled out the tooshie, i did the tummy cause i have a wee bit of padding, lol. Never tried the leg. The injections don't hurt at first, but the further you get the more it smarts, and the big killer is the trigger, it hurt! Same for the Pregnyl after the EPU. Ouch....

But don't let that scare you! You just get it done cause you have to.
xx

Hi ladie's very quiet in here!

All the rest of my medication's are comming today.
I'm starting to get worried what if i don't make enough egg's what if they don't make it to blast stage what if they are all effected what if it dosn't work how do you stay calm? i'm trying to stay positive i am doing my acupuncture avoiding caffine i even lost 2kg's in the last 10 day's what else can i do to help me get throught this and get my BFP.

Hi all,

I agree with Ferrals, very quiet in here for sure.

Ferrals in response to your anxiety!!! I know exactly what you mean. I will commence my Lucrin Injections tomorrow for the start of Cycle #2. I really believe that the first time around I was so much calmer not knowing can be a good thing :). Cycle #1 was cancelled due to not enough eggs :(. I only had one good one and possibly one other and so the heart breaking decision was made to cancel the cycle, only because as you mentioned, there is so many things for the little guys to get through just to get to ET.

Staying calm, well I try my best and am also doing accupuncture. I try and re-assure myself that if its meant to be it will be and just to go with the flow. This sometimes works but for most of it, especially now being so close to starting again, doesnt work too well. I have found that the past couple of nights I have been rather easily upset. I think this is because its all on my mind. Im sure you know when I say all the "What Ifs", especially seeing as I now have something to compare to and worry that it will all end terribly again just like Cycle #1.

All we can do I suppose is provide each other support. It helps knowing there are others out there who know exactly what were all going through and the pressure on us, especially in the PGD area to pull great numbers of eggs.

Ok now i'm freaking just spoke to the pgd nurse about a cycle in dec if this one dosn't work and she said a lot of women have a anovulatory cycle (don't ovulate) after ivf so if that happen's to me she said i might not get a period in dec to do another cycle before the new rebate system kick's in and we won't be able to afford it in the new year WTF! talk about pressure for this cycle to work.

Motherhood-thank's i will do my best to stay calm i just can't believe we managed to make it for oct so we could have another go in dec only to be told that most women have an anovulatory cycle i wish they didd'nt tell me now i would have delt with that issue later now it will be in the back of my mind that this might be our one and only chance at pgd ivf.
Anyway good luck with your injection's i got all my bit's and pieces half hour ago i put them in a bar fridge in our bedroom so kid's wont play with them i'm just waiting for AF due on sunday wish it would hurry up.

A question i flicked through the injection pen booklet and it say's the cartridge should be at room temp before injection but the drug's need to be kept in the fridge so how do all you ladie's do it take it out of fridge half hour before injection or what doe's it matter if it is cold when you inject it? sorry to ask so much i want to make sure i do this right.

Thats strange, best thing to do is check with the PGD nurse, i found with my cycle that you prob shouldn't go by the drug pamphlets anyway cause sometimes the dosage etc is different. Im also confused as last cycle i used lucrin which was fridge stored and now ill use orgalutran which does not need to be refridgerated, however i will check with nurse.

I also couldnt not believe the price difference between lucrin and orgalutran!

Don't stress ferrals... you need to concentrate on this cycle, not future cycles. And even if you say this it it, you will feel differently at some point. Hope your period comes on time and its all smooth.

Motherhood, sounds like we had a similar first cycle, i did get enough eggs but they were poor quality and did not make it to ET. It is upsetting going into a 2nd cycle after a bad 1st cycle, i will be doing it myself in 3 weeks.Stay possitive and make sure you keeps us updated if possible as we will be cheering 4 u.

I have estimated to get my period on the 30th Oct so lets see how accurate i am, lol.

(((((((HUGS)))))))