I have recently been advised to take aspirin for ANA when I next cycle. The Ob that advised me to do this said to commence aspirin following +ve BT. I'm worried that I may never get a +ve result this way and so agreed with DP to start taking it the day after EPU which is the day before TF. My rheumatologist at my appt yesterday told me to not be taking it at the time of TF and to wait 24hrs after TF before starting aspirin.
I just feel so confused atm and am unsure as to what to do. Any opinions, advice, experiences greatly appreciated. TIA.
Hi Dutchie,
I take low dose aspirin every day, when cycling I would stop about 5 days before EPU (on the Colorado Protocol they say to stop 7 days before EPU as they are worried about bleeding during EPU) - but I always pushed the envelope a bit , and would start again the day following EPU and continue. If I was doing a FET I just stayed on it.
Is your FS the same as your OB? I know I have mentioned in the past that daily low dose aspirin seems to be a bit of a standard for immunological or some genetic issues, and the risks of taking it daily are low (especially if it is relatively short term, I have no side effects at all) and I don't want to push you, ultimately it is your body/decision, but I do think it is worth doing some research on.
Same goes for Prednisone and Clexane, they are pretty standard treatments for the above issues and can make the world of difference.
Thinking of you and wishing you all the luck in the world, what ever you decide. xx
Thanks a million BDT, I secretly had hoped you would reply.
My FS is not the same person as the Ob I saw and I don't believe that I will be seeing the Ob again. FS mentioned aspirin and heparin when I mentioned my +ve ANA but didn't mention when to start etc. FS is away atm but when they return, this will be the first thing I ask about.
It's interesting you said aspirin sems to be the standard for immunology and some genetic issues. My rheumatologist said that he uses aspirin as a matter of course in his pg patients with a lot of the auto immune diseases he treats BUT, RA (rheumatoid arthritis) isn't really one of them LMAO (of couse it isn't), however he is happy for me to begin following an ET. He said that it's not good to be on it at the time of TF as it impacts implantation. Now this is where I start to get really confused. I'm not sure if when he says implantation he's referring to implantation of the embryo into the uterus lining or the implantation of the embryo back into the uterus at ET. From what I have read so far aspirin does not negatively impact the embryo implanting into the uterus lining so I'm assuming he was talking about implantation of the embryo back into the uterus. I did check and he definitely said it was ok to start 24hrs after ET. My thinking is this is what I will do, I'd hate to think that I was jeopardising (sp?) treatment in any way by starting too soon but I agree with yourself and CPie- starting after a +ve pg test may be too late and I may never get a BFP if I do. I hope my ramblings have made sense. TIA.
Last edited by Dutchie80; July 8th, 2009 at 08:45 PM.
Hi Dutchie, I would bet anything that when you see your FS they will recommend commencing aspirin right away daily, with Clexane from EPU or ET, and Prednisone for at least 5 days from trigger, if not longer. But...I am not the Dr lol, will look forward to hearing what your FS has to say.
I have read some where that there was some theory that the aspirin could contribute misscarriage in high risk (or previous mc women), which is perhaps where your RA is coming from about being on aspirin at time of implantation? I guess it is all theories. And for me anything was worth a try. But I would definitely push you FS to make sure they are taking your + ANA seriously. Can't wait to see how you go. Big hugs. xx
I have some experince of Asprin so thought I might share what we are doing in case it helps at all;
I am on Aprin (100mg daily) and have been since TTC with this bub (29 weeks pg now). Theory is that due to having a couple of m/c and a small for dates baby previously Asprin would help with avoid another m/c as often the cause is clots forming and would also assit with bubs growth dureing pg. Both have turned out to be true for me.
My DS was on Asprin from birth to 3.5yrs due to heart condition and is now on Warfrin. Asprin is thought to be safe for long term use at the right dose unless stomach issues arise. You can get 100mg tablets of Asprin from supermarkets now.
Also, we were asked to take DS off Asprin 5 days before heart surgery due to needing to have more clotting factor in his blood for surgery - obviously open heart surgery is a pretty bloody operation and I was always told that the Asprin does take 5 days to take full effect and to wear off.
HTH.
Good luck with this cycle!
Last edited by Rommy'sMummy; July 1st, 2009 at 03:42 PM.
: took out ticker
Thanks heaps BDT and RommysMummy.
I guess I will just have to wait and see what the FS says but I have no issues with pushing the boundaries to get a BFP. I have only had one TF thus far but I would hate to do another 4 or 5 without success knowing if I had of used aspirin things might have been different.
BDT- I had also read of aspirin contributing to m/c and I guess this is where my reservations about starting too early have come from. To my knowledge I have no clotting issues, no lupus anti coagulant antibody, no anti cardiolipin antibody and I'm guessing this is why heparin/clexane hasn't been offered to me, only mentioned by FS and this was before I got the results of the immunology tests I had done.
I'll update when I have spoken to my FS, thanks again for your help.
It's hard to know when to keeping trying the way the FS wants, or when to start making decsisions for yourself. I think the FS can be too cautious, whereas I"m more likely to throw everything at it and hope something works. I might have a look on a few UK sites - thanks for the tip.
Just read the thread, very interesting. Im just about to begin my 2nd cycle with Pred and Clexane to treat my high NK cell issue.
Last night, I just realized my left wrist has not feel right for a long time. I have always suspect that I have some kind of mild case of arthritis but not much symptoms, this could be one reason contributed to my high NK cell level - autoimmune disease.
I did a Rheumatoid Factor b/t last year which rule out the possibility, at the same time, I also test ANA, it says Titre, Pattern 80 Homogeneous (screened at a titre of 80). Reading what BDT posted, does it mean that it is over 1:40?
The reason Im asking this is I am wondering if I should add low dose aspirin to the mix of Pred and clexane for this coming cycle. I did share this result with my FS, given the treatment is pretty standard, he asked me not to worry about it, just standard Pred and Clexane.
Cuddlepie, the aspirin is simply going to thin the blood - something the clexane is already doing for you. I'd be inclined not to worry about it - especially as you already have something to prevent clots and your FS says not to.
I was guilty of self-medicating aspirin. But my FS refused to admit that there was a problem, despite three miscarriages - two of which were very early. I was already on prednisone for arthritis and possibly NK cell problems, and had borderline results with lupus anticoagulants. It was on the advice of the woman I saw for acupuncture after first confirming with an OB that it would do no harm if I took it but didn't need it. I started the day after EPU and the cycle where that was added was the cycle that resulted in my first successful pregnancy.
I don't know much about ANA as I never tested for it. if your test result shows a titre of 80 then yes, that is 1:80 which is higher than 1:40 which would be a positive test.
I didn't take clexane or prednisone, so can't comment on these products or what they do. I did end up taking asprin before my last IVF cycle and I got a BFP. As I wrote in my previous post, I"m inclined to throw everything in there (as long as it is safe) ... because at the end of the day, I think it's more important to get your BFP than it is to know what has been causing the infertility. I still don't know what our problem was with conceiving, and although it would be nice to say "it was because of xyz..." I'm just happy that whatever we did differently has worked for us.
So throughout the month before I started injections, i took asprin, royal jelly tablets, elevit, probiotics and high dose multi B vitamins. once i started injections I stopped the asprin (my EPU was 9 days after starting injections and I bled more than on my previous EPU) and after EPU I stopped taking everything except elevit. We did ICSI (we only had 3 eggs) which was new for us and 2 fertlised. we transferred 2 embies because the FS said the second one was not good enough to freeze and we got a BFP. Maybe it was more good luck than good management, but we've got to try something, right?
Its lovely to hear from you BW, lovely avvy by the way.
I did remember you told me before the right dosage of Metformin and adding Aspirin contributed to Sam's conception. I wasn't aware you were not on clexane, somehow I had an impression when you get prednisone, you also be put on clexane. I thought asprin is just an extra medium added to the mix. Anyway, your point sounds very logical, if you get a stronger drug to fix the problem, there is no need for the milder one.
Although ANA/arthritis problem is comparatively new coming onto the horizon for me, Im sure there are some link interrelated to each other with my elevated NK cell level. I don't know why I feel the urge that I need to do sth extra or different if the protocal already cover this bases. I guess the anxiety of facing another failure already get on top of me even its a month away...silly me But talking about it do help!
Daisie, thank you for sharing your story, congratulations! So glad its literally 1st go on asprin brought you a BFP. Sounds like you only took asprin leading up to the cycle and stopped before FSH starts, when you say injection, that means CD1 on FSH right? Amazing just this little drug can make the difference. All the best for the rest of your pregnancy!
When to begin aspirin???
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, and would start again the day following EPU and continue. If I was doing a FET I just stayed on it. 
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