Have you normally been doing the lucrin/puregon shots in the morning? Is the trigger shot coming in the evening? If that's the case, that could be the reason for the lucrin only shot on the morning of the trigger. Part of the reason my clinic liked us to inject in the evenings is because triggers always happen in the evenings and it means we can just have the trigger that day and not have to worry about extra shots in the morning.

I've had OHSS in varying degrees of severity with all three stim cycles. One had me off work for three weeks, another had me in hospital for a week and off work for a month - both of those had no transfer. The third... we'd finally managed to keep levels low enough to have a fresh transfer, but the OHSS developed mildly with a positive pregnancy test. At 13 weeks I still had quite enlarged ovaries... BG has given you the run down on what to do to reduce the severity of OHSS, if it does develop, do not be afraid to take your wife to hospital, it really is the best place for her. It is important to keep eating protein if OHSS develops, I'm not sure why, but it does help things resolve quicker.

Also, because my levels take off so quickly and get so high, it's normal for me to only have lucrin the day before trigger. My puregon shots are gradually reduced, and I'll have a day or two with lucrin only before triggering. It's a normal thing to have happen in cases of OHSS.

My nasty OHSS cases developed with E2 levels of around 15000, I have PCOS which also makes me more prone to developing it. I've heard of other women with E2 levels much higher who have gone on to have a transfer and not develop any symptoms of OHSS. For me, the trouble is more the PCOS rather than the actual E2 numbers.

BW