I'm sorry I haven't been through this or known anyone going through this before, but I have been doing a training course for running a self-esteem program in high schools for girls, and one thing they mention is a drop in self-esteem when a family circumstance changes dramatically. With your wife going through a tough time right now, it has to effect him too.
I would definately think about Lucy's advice and have an up front communication time with him, offer your fears & concerns and allow him to do so also. HTH!
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