I started off putting it around DS's ankle everytime I put him down, but it was such a PITA and always seemed to come off.
In the end I decided to just leave it on while he slept. I figured he always slept in his cot and there was absolutely nothing in there that it could get caught on, so it didn't represent a strangling risk. Also, they are designed to break when under pressure, so there is already a very low strangling risk. If it did break then the beads were individually knotted. If he did end up swallowing the one that came loose, they are so small that they would just pass right through. From memory DS was about 5 or 6 months at this stage and he continued to wear it 24/7 up until recently.
Bookmarks