Cherished, my DS vomits on contact with oral panadol and can't take ibuprofen due to renal issues. On the rare occasions her has required analgesia or an anti-pyretic I have use the PR Panadol (suppositories). They are fantastic, and work very quickly. I use a little bit of lube and wear a glove. My DS is now 6 and lies on his tummy if I need to insert one. As long as he relaxes his bottom there is no discomfort for him. If I have needed to use it, he has been unwell enough that the idea of a suppository doesn't bother him!