Is he distressed the whole time he is there, or for just a little while? My two are masters of putting on a show when I drop them off at creche but I know they are fine 5 mins later as I've hung around and spied through the window to ease my mind.
If it is something you want to persist with then he will get used to it. Make it fun for him and try not to drag out your goodbyes. Tell him that you will be back soon. Maybe have a treat for him in the car (a freddo?) when you pick him up, and tell him he was a good boy and this is for him.

I've had Mason clinging to my ankles so hard that he almost dacked me and I've had to carry him to the room kicking and screaming while he had a handfull of hair so I had to prise that out of his grip. As he is older now he can be reasoned with but he knows when creche day is and refuses to get dressed, or brush his teeth, or get his shoes on, get in the car etc. It is draining but I know he has fun there and some days he even asks to go and play with the kids.
Angus has started copying his brother lately so it's twice as bad some days.
I need my space and they need theirs. I have no family in the area and the friends I have work so I don't really have anyone to mind them for me during the week. Mason has come ahead in leaps and bounds since he has been going to creche. It's only one day a week.
Good luck!