can prednisoline affect my supply

[KimmyF]

Hi Everyone
I have a nasty sinus infection and went to dr yesterday who put me on anitibiotics, some predinsolone and a nasal spray, today I feel my supply is down on normal, DD has been looking for second side when normally she doesn't and I don't feel full like I normally would. I am wondering if it is the prednisolone? I tried to have a bit of a look on google and just got confused! I did the dr I was BF and he said everything was fine to take whilst BF but he didn't mention anything about supply and I was in so much pain I forgot to ask.
Thanks in advance for any info or experiences
kim

[sas85]

I don't know what prednisoline is so sorry about that, but some women have found that sinus medications used for 'drying' the nasal cavities up, seem to 'dry' their milk up a little too.

[Amity]

Pred is a steroid, so it should have no effect on your supply. The nasal spray is the most likely culprit as it "dries up" your nose and will probably effect your supply.

[black_rose]

Stop the nasal spray and get a nasal rinse kit instead it's saline so won't effect your supply and it washes out the goop, it's what my ent recommended after I had sinus surgery.

[Junglemum]

I have taken pred on and off while bf'ing with no issues. I'm not convinced a nasal spray would do it either. It's not going to dry up every fluid in your body surely!!
Are you keeping your fluids up and resting? When I'm sick I find my supply does drop, prob because my body needs energy to heal and steals it from the milk factory.
You could ring the ABA and ask them about the mess though.....

[Khaleesi]

I take Pred a lot & i never had issues because of it.

[HotI]

You can look up effect of medicines on breastfeeding here LactMed Search


Here is some of the info on Prednisolone

Summary of Use during Lactation:
Limited information indicates that maternal doses of prednisolone up to 50 mg produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants. With high maternal doses, avoiding breastfeeding for 4 hours after a dose should markedly decrease the dose received by the infant. However, this maneuver is probably not necessary in most cases.

Drug Levels:
Maternal Levels. Seven women were given 5 mg of radiolabeled prednisolone orally. A total of 0.14% of the total radioactivity was recovered from breastmilk over the next 48 to 61 hours.[1]

After oral prednisolone, levels of 23 to 40 mcg/L occurred with doses of 10 to 20 mg in 3 women, while peak levels of 106 and 137 mcg/L occurred after doses of 30 and 45 mg, respectively, and a peak prednisolone level of 317 mcg/L occurred after a dose of 80 mg. The ratio of the peak milk to peak plasma prednisolone levels were about 0.1 with doses of 20 mg or less, while it was 0.2 with doses of 30 mg or more. The ratios of the areas under the curve reached 0.2 only with an 80 mg dose. The higher ratios with higher doses are thought to be due to saturation of serum protein binding sites. Peak milk prednisolone levels occur about 1 hour after an oral dose of prednisolone and dropped with a half-life similar to the serum half-life. The authors estimated that a breastfed infant would receive less than 0.1% of the mother's total dosage of prednisolone; however, using the higher accepted milk intake value (150 mL/kg daily), this value would be less than 0.015% of the mother's dose.[2]

Three women were given 50 mg of prednisolone sodium phosphate intravenously. Thirty minutes after injection, milk prednisolone concentrations varied from about 200 to 400 mcg/L and dropped with a half-life slightly faster than the 2.5 hour half-life in serum. The authors estimated that a nursing infant would receive an average 0.074% of the total dose administered to the mother.[3]

Infant Levels. Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:
None reported with prednisone or any other corticosteroid. In a prospective follow-up study, 6 nursing mothers reported taking prednisone (dosage unspecified) with no adverse infant effects.[4] There are several reports of mothers breastfeeding during long-term use of corticosteroids with no adverse infant effects: prednisone 10 mg daily (2 infants)[5][6] and prednisolone 5 to 7.5 mg daily (14 infants).[7]


Possible Effects on Lactation:
Published information on the effects of dexamethasone on serum prolactin or on lactation in nursing mothers was not found as of the revision date.

A study of 46 women who delivered an infant before 34 weeks of gestation found that a course of another corticosteroid (betamethasone, 2 intramuscular injections of 11.4 mg of betamethasone 24 hours apart) given between 3 and 9 days before delivery resulted in delayed lactogenesis II and lower average milk volumes during the 10 days after delivery. Milk volume was not affected if the infant was delivered less than 3 days or more than 10 days after the mother received the corticosteroid.[8] An equivalent dosage regimen of prednisolone might have the same effect.

A study of 87 pregnant women found that betamethasone given as above during pregnancy caused a premature stimulation of lactose secretion during pregnancy. Although the increase was statistically significant, the clinical importance appears to be minimal.[9] An equivalent dosage regimen of prednisolone might have the same effect.

[black_rose]

Bm and mucus production are linked which is why it would be lowering your supply.

[KimmyF]

Thanks everyone for taking the time to reply. I have not had the nasal spray today as last night after i went to bed I wondered the same thing. I think i will only use it when my nose is really bad as it works quite quickly. I used it last time when I was BF my DS and didn't recall any drop in supply but i had never taken the prednisoline before so that's why i wondered if it was that. It could also be because I am unwell too, you're right.
Thanks again for your posts, don't know what i'd do without BB

[onthefly]

If you're unwell, you may be a bit dehydrated...? Take care