Thanks again everyone! I'm passing all of this onto my sis for her to read and take in.
kmn - the bottle was formula. She gave him a couple of bottles last night and he was really settled, first time ever, so she is pretty sure it's something in her diet.
jennifer - thank you so much for that link! I've emailed that to my sis as well. I'm really hoping she'll follow through with it. She's getting so tired now, and I worry she's going to give up too soon.
Thanks everyone! You've all been such a great help.