My son who is four had horrible reflux. He was on losec from 12 months when we figured it out and got better - not perfect but better. We now know he has other issues which would have been causing some of his problems too. My other son is nearly two and he has been on Zantac since about 3 months old. He has it morning and night and and goes pretty well - but we know when he misses it! Does she have her medicine spaced out? Maybe check in with dr again about the dosage and time it's given? Has she had her ears checked? Perhaps it's causing referred pain for her to swallow? Hope you figure it out soon.