the current recomendations for panadol and neurofen is to actually give them together. This achieves a longer and better pain relief. It has been discovered that by staggering the dose (give one and then 2 hours later give the other), you are actually cutting off the first medications signals to the pain receptors therefor stopping it from achieving it's full optimal pain relief. It is safe to give them together. Because they have different dose times, give it at the longest duration (which would be the neurofen which is 6hrly).

MG