I take diabex XR, have done for 6yrs. I found I was nauseas if I didn't take it with food. Best time for me is at night with my dinner. When not pregnant I have been known to have to increase to a 1500mg dose and it stops the nausea. I do sometimes feel very hungry in the morning though depending on what my dinner was the night before. At the moment I am on 250mg as I found I just couldn't eat at all (no appetite at all - normal dose is 1 tablet 500mg) in early stages of PG. Also when I first starting increasing I would do one day inc increase the following old dose until I felt better on the mornings I had the increased dose.