I really think that it depends on the individual.Like Danni has said it made her soooo sick. My gyno mentioned it but was unwilling to prescribe it to me as my PCOS symptoms were minimal, I'm not overweight and no insulin probems. I was lucky though as clomid works a treat for me and for my sister who also has PCOS in a mild form. Met seems to work so well in some and clomid does in others. I must say though I would be unwilling to take it as it is a insulin reducing drug and like Danni's reaction I would be scared that I might have an adverse affect on it.