You need to diffuse all guilt before any meaningful conversation can take place.
I think that's critical! Guilt in a person so often manifests as anger, because they resent feeling guilty and culpable...when an open conversation would dissipate a lot of that feeling of culpability!
Understanding that it's not their 'fault' is probably a huge stepping stone here, but worth the effort of getting to that point.
Excellent point, Mags