My DD has S-26 Gold. She used to get constipation but I gave her the warm cooled boiled water and it did the trick. Only rarely does she get it now. She's been a lot better in the last month. She is 3 months old now. I think it is just that their digestive system is immature and sometimes cannot cope. At first I had my DD on Karicare(yes it does stink doesn it!) and it make her get very bad diarreha(?sp) and that is when i changed to S-26.