Cream is only for relief of external symptoms. Diflucan is a one off tablet, which gets rid of fungal infections in your body - but wont give quick relief for external symptoms. I find garlic to be VERY effective though, and cut back sugar (which thrush will thrive on) and yeast while having treatment. I also pump up my level of probiotics and take garlic orally, but you should get a good brand like medi-herb which coat the tablet so it breaks down in your intestine. Garlic is brilliant (ideally fresh) as it has many properties, anti-viral, anti-fungal and anti-bacterial.