i had the exact same problem with lani - i can distinctly remember (like it was yesterday) driving to my ob's for our 6 wk follow up visit with lani screaming and ds holding his hands over his ears most of the way.
i found lani's problem was the brightness/sunlight coming into the car. i just brought some of those window sox thingy's from super cheap auto to put over the back windows and it really did the trick for me. i also moved ds booster seat next to lani and when she got upset he used to hold her hand and talk to her (or give her a dummy if necessary) but i really feel now that it was the sunshine and light hurting her eyes.
good luck - i know it is sooooooo frustrating trying to concentrate on driving whilst having to listen to them cry
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