i haven't used depo, but two close friends have, one loved it but gained massive amounts of weight whilst on it, she fell pregnant pretty much straight after coming off it, she went back on it between bubs and took around 10 months to fall again. She is planning to go back on it after her next bub is born and stopped BF. My other friend had one needle, she lost all hre libido, was depressed and emotional and started gaining weight, she never had another injection after that and it took over 6 months for her cycle to return to normal.
HTH