thread: Help - wtf is going on with my response to puregon?

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  1. #1
    Registered User

    Jul 2006
    Melbourne
    4,895

    Aww, I know it is crappy. I hope it is nothing to worry about though. Last time I did IUI it took a while for me to respond then all of a sudden my follies took off on no increase to puregon - go figure!

  2. #2
    BellyBelly Life Subscriber

    Jan 2006
    11,633

    Have you had a scan at all?
    It really sucks when **** like this happens - hope your cycle still works out.

  3. #3
    Registered User

    May 2007
    Otago, NZ
    877

    Hey Marcellus

    I go for a scan and another BT on Friday which feels like an absolute eternity away right now iykwim.

    Hoping like mad that I am just a slow starter this time round.

  4. #4
    Registered User

    Dec 2005
    6,706

    Hi... just wondering... do you have PCOS at all? It can lead to a really unpredictable response to puregon and other stim drugs.

    Unfortunately, there's no real way to know how likely you are to overstim until you get there. I had OHSS with all three of my cycles - the first two were so bad I was unable to have a transfer and with one of them I spent a week in hospital with it. I know how scary it is.

    BW

  5. #5
    Registered User

    May 2007
    Otago, NZ
    877

    Hi BW - nope no PCOS here that we know of but our initial problem as to why we had to do IVF/ICSI was MFI and no real investigations were done on me other than my immune issues. We were quite surprised at my response from our first cycle though. I did a sneaky little E2 today (one of the few perks of working in the lab) and it has more than doubled since yesterday's test. Is this ok or does it tend to rise quite quickly once the response kicks in?

    I was frantically trawling through BB last night trying to get some answers - wow you really had to go through the wringer to get your wee boy. Thanks for your input

  6. #6
    Registered User

    Dec 2005
    6,706

    Mine would always rise quickly once it got going. They needed a high dose to get me started and then the rest of the cycle was daily blood tests and puregon dose reductions.

    But I have severe PCOS and they kind of expected that with me.

    BW

  7. #7
    Registered User

    Jul 2006
    In The Land Of Wonderful...
    1,751

    Hi

    Upping the dose like that won't doom your cycle In a lot of cases, you'll find that FS' will move the dosage around from blood test to blood test (it's happened to me) - I've gone from 150iu up to 300iu down to 250iu all in the same cycle - the constant bloods plus the scans will tell your FS what to do

    I don't have a lot of advice re the over stimming... my cycles were always up & down with unit dosages, and I didn't get over stimming in any - but I don't have any history of PCOS, either.
    This cycle might just have been a slow start hun.... I can say from experience (and I know BW will back me up here) - that sometimes the cycles you think are the crappiest, and you want to just be done with and start again, are the most successful

    One of my crappiest cycles resulted in Carmelo... and BW got her DS as a result of a cycle that she had no hope for, either

    Best of luck that this cycle is the one for you!

  8. #8
    Registered User

    May 2007
    Otago, NZ
    877

    Thanks so much for all of your responses - I am definitely feeling a lot calmer about things now. We had to cancel our last cycle cos I found out I was coeliac, along with other blood tests that showed dodgy antibodies and I had this horrible moment of panic yesterday that we may be faced with another cancellation. I spoke to my nurse today and she was really reassuring as well.

    BW & Hollybolly - it is so great talking to people who have come out the other side of this and have their little bubbas - keeps the hope there.