I think crinone is more effective compared to pessaries especially if the pessaries are used vaginally. At my clinic they now do pessaries rectally and have had better results with maintaining progesterone levels.

I have normally used crinone in the 2WW and then pessaries when pg. Actually last cycle I used both until 13 weeks pg to ensure my P4 levels stayed up but I think that was unusual (2 crinone and 8 pessaries a day!).

Crinone is absorbed more fully into the uterus and may not show up as high on the blood tests which can cause some people to worry but it is quite strong. Both have side effects but I think the crinone is more iterating on the cervix and can cause some brown discharge.

I can recommend the pessaries rectally as you are sure they have stayed in longer (ie don't leak like they do vaginally) and absorbed more. That said after using them until 13 weeks pg they irritated my bowel too.

Well that is probably TMI but I took a ridiculous amount when pg with my DD so got to know them both well.