I did mine at 9 pm every night, and for me the orgalutran needle hurt a little bit more than the gonal/puregon, but I think that's because it's slightly a thicker needle. The gonal/puregon needles are so thin I think. Do the same with the orgalutran (morning needle), as in pinch the skin quite hard so you don't feel the needle going in so much. I found that if I inserted the orgalutran needle at a funny angle, it hurt more. Other times it was OK. GL sweets