I always did the same as N2l (morning, as soon as I got home from work and bedtime), but I was told "back door" was an option too. I always felt uncomfortable with the idea of using them rectally even though I too had heard they are better absorbed that way (along with the other benefits)... But I'm someone who never used tampons because I didn't like inserting them, so I've come a long way to overcome that aversion just to use the pessaries vaginally in the first place!