I was on a one per day dose from the day of my BFP til about 11/12 weeks. They say you should lay down for awhile afterwards so if you're on once a day best do it before you go to bed.

I also got thrush from them if used vaginally, so I switched to rectally (ew I know but so much better in the long run!). Apparently they're absorbed better rectally as well.

Good luck!