Page 2 of 2 FirstFirst 12
Results 19 to 23 of 23

Thread: Interesting Article..

  1. #19

    Join Date
    Dec 2005
    Location
    Bendigo, Vic
    Posts
    667

    Default

    In response to Keen's post and Sue's suggestion to move back in here...
    Quote:
    Study Finds How Embryo Sticks To Uterus
    January 16, 2003
    WASHINGTON (AP) -- In research that could lead both to new ways to treat infertility and new types of contraceptives, scientists have identified molecules that help embryos stick to the wall of the uterus.

    Timing is everything, the study shows.

    By analyzing carbohydrate molecules on the surface of the uterus during different times of the female cycle and by identifying a protein, called L-selectin, on the surface of the embryo, researchers at the University of California, San Francisco, learned for the first time how the embryo sticks to the wall.

    Susan J. Fisher said coatings on the uterus and on the surface of the embryo act like puzzle pieces that touch and quickly lock.

    "One piece of the puzzle is a protein on the embryo and the other is a very specialized carbohydrate sugar structure," said Fisher.

    The sugar molecule on the surface of the uterus is secreted for only a short time during a woman's monthly cycle and the embryo, with its L-selectin coating, must arrive at the uterus during this time.

    "It has to take place in exact synchrony or you don't get pregnant," said Fisher, noting that failure to implant on the uterus is one of the most common causes of a failed conception.

    "Only 50 to 60 percent of all conceptions advance beyond 20 weeks and of pregnancies that are lost, 75 percent represent a failure of implantation," she said.

    With this understanding of implantation, researchers may find new ways to help women time their efforts to get pregnant, both naturally and in fertility clinics.

    Fisher said it may be possible in fertility clinics to coat embryos with the sugar molecule and help uterus adhesion.

    "If we can launch the implantation (process) in the culture dish then you might be able to implant fewer embryos and have greater certainty" of a successful pregnancy, she said. Currently, fertility clinics can prompt successful pregnancies 25 to 40 percent of the time. By more precisely timing implantation, based on the readiness of the uterus to adhere to the embryo, these chances could improve, said Fisher.

    ......

    Dr. Phyllis Leppert, chief of the reproductive science branch of the National Institute of Child Health and Human Development, said the discovery by Fisher and her co-authors "is a breakthrough" that may lead to fundamental new treatments for pre-eclampsia and for a major cause of infertility, poor adhesion to the uterus after conception.

    "This is a new lead that we can pursue," she said.
    This is a subject that has been really on my mind, and even more so since my last failure. I've been trying to do a bit of research on this type of thing and other endocrine abnormalities.

    Thanks Keen for posting this. I'm going to ask my FS about this when I see him on 26th.

    I hadn't heard of this but had been trying to find out more about beta3-integrin which some clinics test for. Apparently if you don't have beta3-integrin the embryo can't implant. I'm still trying to find out more about this test and others that might help with diagnosing this kind of problem.

    Apparently the lining is only ready for 2 days each month and that 2 days can be really out of whack with your ovulation if you have a luteal phase defect.



    Has anyone had tests for this type of thing? My clinic just seems to go on the thickness of the lining.

  2. #20

    Join Date
    Aug 2005
    Location
    NSW
    Posts
    842

    Default

    Hi Kar
    I was never tested for that.
    My clinic for my last two cycles were looking for a triple lined uterus (I think that's what they called it)? I asked about thickness and they told me they just look for the triple line. Still not sure what that means as the scientist didn't give a very good explanation.
    Sue

  3. #21

    Join Date
    Dec 2005
    Location
    Bendigo, Vic
    Posts
    667

    Default

    Sue
    I seem to recall that term being used as well.

    One of the nurses at my clinic also called it the leaf shape.

    I think the triple line may refer to how the endometrium looks on the ultrasound. The three lines refer to the lining on the walls of the uterus and the infitessimal gap between. Sort of the two slices of buttered bread thing, only leaf shaped or with the appearance of three lines.

    Not sure though... could just be one of my imaginary theories.

  4. #22

    Join Date
    Dec 2005
    Location
    Bendigo, Vic
    Posts
    667

    Default Accupuncture and Hypnotherapy assist ET Articles

    Hi All
    I have a growing collection of articles about the (favourable) effect of accupuncture and now even one on hypnosis and ET.

    Most are from this year so they are very recent.

    If anyone wants copies PM me and I'll send you the PDFs.

    EDITTED TO ADD: I have now put the articles on my webpage (well most of them! there are heaps so I'll keep updating it from now on) - the site is listed in my profile.

  5. #23

    Join Date
    Dec 2005
    Location
    Bendigo, Vic
    Posts
    667

    Default Cumulative pregnancy rate by age Articles

    I also have a number of recent medical journal articles about the cumulative probability of pregnancy through a number of cycles - some break this down by age, type of subfertility, icsi/ivf or other categories that can be insightful.

    If you want something PM me.

    I'm going to try to list them more comprehensively on my website when I get that up and running.

    EDITTED TO ADD: I have now put the articles on my webpage (well most of them! there are heaps so I'll keep updating it from now on) - the site is listed in my profile

Page 2 of 2 FirstFirst 12

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •