Welcome to IVF with PGD forum. This forum is for those that are undergoing IVF with Preimplantation Genetic Diagnosis..
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Thank you so much ladies....
One thing i will say is thinking back to our very first appointment with the geneticist is that he told us that statistically it could take 3 FRESH PGD cycles. At the time i thought pfft no way, but here we are 3 fresh cycles later.
The reason i am telling you this is because i know you all struggle with wether PGD is worth it sometimes. And for us it was easy as we had no other choice.
xoxo
I"m joining this forum for the first time... I'm undergoing my first IVF cycle with Pgd and I'm just really looking forward to learning from your experiences and hopefully finding some wisdom in your words when times are tough.
Hi Kimmi, I wanted to wish you the best of luck for your first cycle. Hopefully it only takes one cycle for you It took us two cycles to fall pregnant with our precious little Apple Blossom, but we had some really bad luck with chromosomal abnormalities with our little embies. Fingers crossed you will have much better luck.
I think the best advice I can give is to not stress to much about things (yeah yeah I know, it's much easier to say than to actually do, lol). To be honest, I'd read so many horror stories about how hard IVF is, and how sick the drugs can make you etc etc, that I was rather worried when we started. But I must admit that it was much easier than I had expected. Of course it was devastating when we got bad news with our first cycle, and then it was heartbreaking when we found out that in our 2nd cycle we had only one healthy embie from 21 eggs, but one was all it took for us! So it just goes to show that you just need to stay positive and little miracles can and will happen!!!
Aww thanks for the reassurance Mylitta! I will most definitely take your advice on board, and like you, I am not (so far) finding the medications any where near as bad as I thought they were going to be. I had a small shocker on the weekend, which I can only attribute to Cetrotide, but other than that, I've been fine. I even managed to get to the gym this morning at 5:30!
I'm having a scan tomorrow and that will determine if I have my epu on Friday or Monday. I'm hoping Friday, but happy either way.
At my last scan, I only had 6 Follicles reasonable follicles and many smaller ones, so here's hoping the little baby ones have grown.
I have severe PCOS which is where our fertility issues come from, and then DP is a carrier for Chromosomal issues that previously caused the death of his brother and sister, so we are absolutely keen to avoid that, hence the PGD.
I am feeling good about it all, optimistic, but certainly not expecting a miracle this time around.
I really look forward to getting to know you ladies much better.
Hope your cycle continues to go well. I found mine went better each time, in all ways.. emotionally, physically and of course successfully.
My advise would be that if you are determined to not pass on DP's gene do not give up on PGD. It is a much harder journey than regular IVF and i almost gave up so many times. But like is said each cycle your FS will learn and you should find more success.
x
I just realised that I said fresh cycles, and I probably should have said full stim cycles. I am sure though you all knew what I meant Probably shouldnt post when it is so late and I should be sleeping.
Anyway, not sure I really want to be the record holder in this area! Did Foxy have a translocation issue?
EJE - no, for me it was for recurrent miscarriage/failed IVF after multiple embryo transfers. We did 2 fresh PGD cycles, 2 regular fresh IVF cycles and 5 FETs. I am incredibly impressed that you have survived 9 fresh PGD cycles. How are you going? What are your specialists recommending? How are you feeling about it all? Have you been getting "normal" embryos? Have you been tested for immune issues including NK cells/have you had any pregnancies since starting the PGD and been tested for recurrent miscarriage (I guess this is how your translocation was found)? Where are you doing PGD? Hope not too many questions. I am in awe of you.
We found out that DH had a balanced translocation (18 & 21) after many miscarriages. We were tested for everything but not sure if that included NK cells- what is this? And the karytope test revealed the translocation. We then found out about PGD Ivf and once our probe was built did our first cycle. That cycle collected 12 eggs, and 4 were suitable for testing and of those one was fine. That one is now our precious 3 year old boy . Since he was one we have no attempted 8 more for a sibling. I am what you call a good chicken and produce lots of eggs on low doses of fsh. The lowest number has been 15 eggs, and the last 2 cycles we have had 21 and 22. We have good fertilization rates, using Icsi ( even thought we don't need to use Icsi, we do just to make sure we have good fertilisation iykwim) . Last cycle was had 15 fertilise and 10 to biopsy/test. All 10 had the translocation. Cycle before we had 8 to test and again all carried the translocation. We had another cycle where although we only had 5 to test 2 amazingly were fine. We put both back in / transferred both but for some reason they didn't make it.
We are with MIVF.
Do you have any suggestions for what we could do differently? I have done some cycles with accupuncture, but this doesn't seem to have made a difference.
On a side note, I have underactive thyroid and pcos, and seem to get ohss everytime, including when I was pg with ds. Ohss is REALLY horrid.
Oh and Molisa thanks for those stats. We have basically been told that on paper for us that I in every 10 biopsied/ tested we should get one that is fine. Butbeven though we have had cycles with 10 to test thus doesnt seem to be the way it works in the real worl iykwim. Seems to be more a case of genetic tatslotto. Can I ask who your scientist is with?
You are very very fertile. What you do or not do don't alter the likelihood of a balanced chromosome set occurring. That 1 in 10 likelihood is estimated by your scientist specifically for your DH's involved chromosomes and breakpoints? What I was told by my lab is they observed 1 in 4 is genetically balanced from their own data. It can 'vary according to the amount of chromosome involved and which chromosomes are involved but seems to vary from run to run'. I also searched some technical literature and the reported sperm normal rate for male BT varies from 20%-50% based on the FISH analysis. But my scientist also commented that 'testing of sperm is error prone and does not necessarily give accurate detail on the true % normality'.
I joined a BT Yahoo group and there are many BT couples from all over the world. I don't check it very often. But last time I checked I saw a couple hit the genetic lottery and they naturally conceived a completely normal baby (not even a BT carrier). Another couple from the USA got 3 fine ones out of 14 tested.
IVF with PGD #6
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