Hi ladies. We may be doing IVF with PGD this year. Do you mind if I ask some questions of those who have been there, done that? We have an appointment with a new FS next week and will be asking her advice as well. The main choice for us is whether or not to try IVF with my own eggs first or go straight to donor eggs. Either way, we'll be doing PGD, as we've had enough late losses for our lifetimes. Our current FS advised us not to waste money on PGD and just have an amnio, which is one reason for changing FS. We're going through Monash IVF.

DS1 had ARPKD, which usually has a 1 in 4 chance of occurrence, but his version was a bit strange. It may be they cannot test for that either, or if they do, they wouldn't be able to give us a definite answer as to whether or not an embryo was affected. If they can develop a test, I understand they'd have to do a feasibility study first, then develop a specific probe, which could take months. Any idea how much that costs? We'll need to discuss that with a genetic counsellor at Monash IVF. Unfortunately for us, we cannot test for DS2's condition as we don't know what it was. Therefore, we don't know if it could occur again.

My AMH was tested in July and was 1. I will have it tested again this month. It may be the result determines whether or not we try with my eggs. If we're only likely to get 2 or 3 eggs from a cycle, then the drop off using PGD would be high. That's a decision we'll make based on what the new FS advises. Is it right that with such a low AMH, that IVF may not work for us?

My understanding is that with Monash IVF, assuming eggs are collected and fertilised, they grow them to 5 days, take a cell to test and freeze the embies. The cells are sent to the USA for SNP testing, which looks at all 24 chromosomes and a bunch of other stuff. This can take 3+ weeks. If there is an unaffected emby, then it is tansferred in an FET cycle and fingers crossed. I assume my early losses are due to chromosome abnormalities, probably relating to my age. I'd like to rule that out if possible. I have some VARTA data, and it looks like Monash has a higher success with FETs than stim cycles. Is this generally true?

We have friends who recently got pregnant on a ED cycle in Spain. They used PGD. A cell was tested from a day 3 embryo and transfer was day 5 or 6 I think. Their donor was 22 years old. Out of 9 eggs collected, 8 fertilised. Of them, 6 made it to day 3 testing. 3 of the 6 had chromosome problems. 2 embryos were transferred and the 3rd wasn't considered good enough to freeze. They are pregnant with a singleton. I find the drop off interesting, even in eggs from a much younger woman. With my age and AMH level, I don't have great expectations using my own eggs.

I understand Melbourne IVF does day 3 PGD testing, but that it's not as accurate as testing a day 5 blast. Does anyone have any experience with both?

I'm yet to make an appointment with the PGD counsellor, so a lot of this we may cover with her, but any other information will help. Thanks.