Just came back from Dr. S appt and got a big shock when he told me that the result is very high, its 30.7% and activation increasedby CD 69 marker.... He said it can be treated by immune supressive treatment such as pendisone (spenlling?) and Clexane injection but he seems to be reluctant to go in details as I am currently still with SIVF. I was a bit dissappointed but I do understand his position as he doesn't want to impose on another doctor's treatment plan.
Apart from the big shock, I am so glad I did this test and finally find sth wrong with me. Weird I know. But this soon is replaced by so many questions and anxiety and I am a bit scared too. How effective the treatment is? What exactly it is involved, any sideeffect? I know quite few of you have been on the treatment of pendisone and Clexane, but can't exactly remember if it is for the same reason, ie. Farmgirl, BW and WLB...
Then of course the question of should I stay with Dr. Lok or change to Dr.S given he is the expert in this field. Is the treatment quite standard? Or it does take a bit experitise to assess your case and adjust dose etc?
How would it affect pregnancy if you do get pregnant? How long does it last into pregnancy?
I am also about to start Antagonist cycle and now thinking maybe I should give myself a bit time to digest, to form a treatment plan. On the other hand, maybe I can just do one cycle with no transfer? My head is going to explore!
I am so sorry that I need to ask all these questions, I should have taken more mental note when others discuss this problem in the past. I am also digging some of the old thread to get a grip on this concept. Any help would be much appreciated girls.
wow. It's always such a shock when you finally get your answer.
Personally, I'd switch to Dr S. But it would be worth discussing your results with Dr Lok first to see what he thinks.
From memory, the treatment is 20mg of prednisone from transfer until 12 weeks when you begin to wean off. I had to alter that as we were also trying to juggle other medical problems as well, and I didn't ever end up coming off prednisone through the entire pregnancy. I believe you will be on the clexane much longer, but I don't know the details there as I used aspirin.
Side effects of prednisone - weight gain, altered moods (makes me irritable). Seems to increase carbohydrate cravings. The weight you gain will centre on the belly... A friend describes the prednisone look as a potato with sticks stuck in for arms and legs. Horrid moon face. I have difficulty remembering as it's been a drug I've been on for so long... it does deplete calcium reserves so it will be important that you take an extra calcium supplement while you take it so you don't end up with osteoporosis later in life. Basically, prednisone turns me into a fat and grumpy cow. It is important that you wean off it slowly. Even if you take it only for the TWW, you'll then spend the next 4 weeks weaning off the drug.
The treatment does seem to be pretty effective, but I wouldn't know exact figures.
It is a lot to digest... but there's also the apparent changes to medicare rebates next year to consider as well.
I hope this has helped in some way - I wish I could remember more for you!
Hi CPie, Just sending a , really happy that you have now found something that can be treated. Sorry can't give any advice on it. Personally I would ask Dr Lok what he suggests.
CP remember what Dr S said on your first visit, well at least he did to me.
The results of research into NK cells and their possible impact on conception and pregnancy is not clear on whether they have an impact or not and is not particularly scientifically rigorous due to limited results and the absence of control groups etc. He was pretty clear with me at my consultation that going through these range of tests can raise more questions than they will maybe be able to answer. I am sorry that you have been put in this predicament .
Also the treatment for possible impacts of NK cells is also not proven and in some ways is still in its early days. I have heard around the traps (and have nothing but chat to base this on as yet) that some FS who have been using prednisolone treatments for LTers are now going off its use for a range of reasons. Something your Dr L may also have some thoughts and information about.
In the end you can only arm yourself with as much information as you can, and with guidance of specialists like Dr S and Dr L make a decision which way you want to go.
I can?t write much more ATM sorry but on the issue of your next cycle, perhaps delay it for a month if that wouldn?t cause you too many problems so you can get the information and advice you need before deciding on your next step.
Thanks Dusty. I don't think Dr.S actually make it really clear until this time. I somehow had an impression that he is an expert in this area and would jump to the opportunity to fix my problem, to my dissappointment, he is quite vague about it and mentioned along the smiliar line of 'no proven research' that NK cell definitely is the reason for my 'implantation failure', given my age, it also could be egg quality and other reasone. He also said the same thing that the treatment is still at early stage, maybe that is why he didn't give me a detailed plan just said different doctors can have different treatment plan etc. I do understand being current under another doctor's care, he might not be able to say too much.
So seems my next step is to consult my current FS and see what his opinion is and then decide what to do. Thanks guys for your help.
Was that result from the blood tests or the biopsy? I had/have a 36% NK level on biopsy, my blood levels were normal however. So I am on 25mg prednisone and 20mg (?) of clexane daily from O date till at least 12 -15 weeks if get a pos HCG. The hardest part is having to wean off between cycles as you have to wean off prednisone very slowly so as not to get adrenal shock.
I am surprised by Gavin's response in terms of treatment but then it may be different because I am in a different state. he seems quite happy to liaise with my specialist down here re dosages etc.....
Hi CPie, Im sorry I have no advice to offer you I just wanted to wish you good luck. Having a result like this must be a real shock to the system, I really hope that between you, Dr L and Dr S you will be able to form a plan that overcomes this issue.
NK Cell result back - Very high
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, really happy that you have now found something that can be treated. Sorry can't give any advice on it. Personally I would ask Dr Lok what he suggests. 
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Immunology Prothrombin Gene/ NK Cells
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