I don't think mthfr testing is common in Australia. The genes have only recently been identified. Often they'll test homosycteine (sp) levels, as elevated levels can indicate a mthfr mutation. However, apparently they can be normal and still have a mthfr mutation.
There are also a multitude of individual genes which your could both be carriers for. Unfortunately, unless they know what to look for, they can't often find it. It may be worth having a micro array done. It's a panel of extended chromosomal/genetic tests they do in addition to standard counting the chromosomes (karotyping).
And as my genetic counsellor pointed out, genetic testing isn't 100% accurate. Sometimes they find things, sometimes they don't. Even with standard tests like cystic fibrosis carrier status, they've only identified 12 possible mutations out of how many unknown ones. But it's better than doing nothing and they're discovering new things all the time.
Have you ever had the babies tested after a miscarriage? Sometimes they can find things, depending on gestation and time since death.
Another things is it is apparently possible to develop an immune response to embryos. I don't know what that's called or if they can test for it, but worth asking about.
I think it was minnie mouse who contemplated IVF for repeated miscarriages. I went through QFG and they were fantastic. If you can, get yourself into Bob Watson, he is amazing!
Freya: firstly im sorry you are going through another loss, as Maruschke said i have also suffered multiple miscarriages and i think it was me who Lenny was referring to.
i started a thread asking if ivf was a "treatment" for recurrent miscarriage, my short story is i have had 2 children and then had two 9 week miscarriages and also 2 5 week miscarriages, the 9 week ones we had seen a slow heartbeat both times but bub was measuring behind, to me that seemed to indicate poor egg quality.
i have had lots of testing done and nothing came up in my blood tests, we have also had the chromosome testing done with myself and DH and both was fine, the fs have said seeing as though we already have a boy and a girl it would be unlikely to be some genetic problem
i always said there was no way i was doing IVF (both my children were conceived with clomid) and i didn't think i could put us all through it however i decided i wanted this whole experience to be over and i thought ivf could give us the best chance of that, it will settle this one way or the other for us.
so im currently doing an ivf cycle and i will be having egg pick up on thursday so i guess we will see how many fertilised eggs i get then, i don't know if this is the answer for us but i figure them being able to look at the embryos and hopefully choosing the one that seems the strongest might give us the best chance of having a sticky one. PM me if you want
I had to have hormone assistance due to repeated miscarriages - I'm now on pregnancy #10. I can fall pregnant at the drop of a hat seemingly but just as easily lose them. I'm 41.5 and last year when I had 4 in a row I was worried it was nature's way of telling me my eggs were too old and it was chromosomal anomalies that were causing them so headed off to a FS. I had the dye test as well as an enormous barrage of blood tests.
Given that I don't have trouble with conception they figured I probably didn't have problems with ovulation so I was monitored for the first two weeks with blood tests, an ultrasound at 9DPO to check on follicle growth, given a trigger shot of pregnyl for ovulation. I then had 1500iu pregnyl injections every three days during the TWW. Following my positive BT I continued with 5000 pregnyl injections three times a week, progesterone tablets 2 x 4 times daily and asprin daily. That regime continued until I got to 13 weeks and from that point only the asprin is continuing.
Their suggested plan had been to start with this regime and if no success within four months then to look at IVF. Fortunately I didn't need to go down that road.
I'm really sorry to hear you've had another loss. Having never experienced difficulty with conception I don't understand that particular road, but I do understand the heartbreak of the rollercoaster that is conception, loss and then finding the strength to start over again. Good luck.
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im sorry you are going through another loss, as Maruschke said i have also suffered multiple miscarriages and i think it was me who Lenny was referring to.
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