A girlfriend of mine's husband has a genetic abnormality and they conceived on their first try using IVF/PGD. Unfortunately they have had a number of further cycles which have only resulted in one "normal" embryo which didn't implant. It's a numbers game.

I suggest you find out using karyotyping exactly what your DH/DP's genetic issue is, and that will assist you in determining the avenue of treatment/options available to you.

Good luck.