NK Cell Test - Help with Undestanding the results

[JustOneMore]

Hi,

I have a couple question regarding NK Cell test and what the results mean.

Question No 1: Total NK Cells (CD3- 56+), What percentage level is classed as normal.

On My sisters test result her level was 19.8% and they said that was classed as Very Very High levels. She requires Prednisilone and Clexane for her future IVF cycles.


Question No. 2: On my results for the NK Test there was hand writing on my test from lab regarding, Activited (CD69+) dim NK’S, does anyone know anything about this?
A lot of the NK tests do not have this information written on it as it is only done if your doctor specifically requests it and if they specialises in immunology.

Mine reads as Activited (CD69+) dim NK’S = 2-1% = 4.2 x 10 6/L

Does anyone know what percentage this should be and what percentage rate is considered as high and low.


Quote:
Originally Posted by Inanna View Post
The NK cell is the most abundant immune cell infiltrating the womb implantation site. In a previous study, an elevated percentage of peripheral blood NK cells were associated with recurrent failed IVF-ET treatment cycles. Another study showed that increased peripheral blood NK cell toxicity was associated with an increased rate of recurrent failed implantation after IVF-ET treatment. More recent studies have confirmed elevated NK cell CD69 expression as being associated with recurrent miscarriage and infertility of unknown reason.

I also found this on a UK site: But I don’t know if there tests are done differently to ours:

• The NK cell is the most abundant immune cell infiltrating the womb implantation site. In a previous study, an elevated percentage of peripheral blood NK cells were associated with recurrent failed IVF-ET treatment cycles. Another study showed that increased peripheral blood NK cell toxicity was associated with an increased rate of recurrent failed implantation after IVF-ET treatment. More recent studies have confirmed elevated NK cell CD69 expression as being associated with recurrent miscarriage and infertility of unknown aetiology. Finally, a recent small non-randomised study has also suggested elevated NK cell CD69 expression may be related to failed implantation of the embryo.

We also recently conducted a study to evaluate the effect of the absolute count of the activation marker (CD69) and inhibitor marker (CD94) expression on peripheral blood NK cells on implantation and miscarriage rates after IVF-ET treatment. It was a randomised prospective observation study of 138 randomly selected women who underwent IVF-ET treatment from December 2002 to September 2003. Our data suggests that an elevated level of CD69+ peripheral blood NK cells is a detrimental factor for implantation of embryos in IVF-ET treatment. Those women who have an elevated peripheral blood CD69+ NK cell count achieve a positive pregnancy from IVF-ET have a significantly higher risk of miscarriage. The specificity and positive predictive value of predicting IVF-ET outcome for women who have a peripheral CD69+ NK cell count above 1.0 x10 6 /L are 92.1% and 92.3% respectively. This test may therefore be used in clinical practice to predict negative outcome of IVF-ET treatment.

Any information is greatly appreciated.