on 100 i didn't respond at all
150 - one dominant follie
175 - one dominant follie
200 - between one and three dominant follies - and up to 30 large follies so high OHSS risk
300 - 59 dominant follies, 22 eggs, 11 mature, five fertilised
umm us ivf # 1 =125 of gonal f =2eggs no fert no transfer
ivf # 2 =225 of gonal f=9 eggs 2 embies bfn
ivf # 3 =225 of gonal f=12 eggs 7 fert a bfp and 5 frozen bubs left
i cant really remember how many follies but hun soz
OK, straining my brain to remember this now but pretty sure for us we started on 125 gonal f and I had no response so FS didn't muck around, upped it to 300. I had only 8 dominant follies on our last scan before epu but had 14 eggs collected, 100% fertilized and we had 11 embies, one transferred, 10 frosties left.
That was all from one ovary, my left has been partially removed and didn't produce any mature eggs.
1st IVF = 200 - 22 eggs collected, 11 fertilised, 4 survived (day 3), 2 ET all BFN, 1 died during thawing.
2nd IVF = 175 - but my level was very high at BT and FS reduced it to 75 for the last couple of days. Had ~10 follies and some smaller ones. 12 eggs collected, 11 fertilised. All grew to day 5. 1 fresh transferred (early m/c), freeze 5 (the other five they chuck). 1 FET (BFP).
ok, had to look for my diary from last year lol!
I was started on 150 puregon, first injection on a Friday morning.
First scan on the 6th day (following Wednesday) , wasn't allowed to do injection until after the scan. Stayed on 150.
Another scan 2 days later on Friday. No injection that day.
Had 14 follies, with a 15th that was on the small side. 15 eggs collected and was told they were a little immature. 11 fertilised, 2 days later for transfer, told that 1 had stopped growing, they didn't know why, another hadn't formed properly or something to that effect.
1 put back, 8 snowbubs
started on 150IU on day 4 (late start!)
went up to 200IU on about day 8 after first blood test
only 1 dominant follicle (4 small ones) and they talked about cancelling the cycle, but then we decided to focus on growing the group of smaller follicles
scan/BT ... scan/BT ... scan/BT etc. until day 14 scan, 7-9 follicles
EPU day 16 - they found 17 eggs (don't know where!!)
1 x blast transfer(BFP); 8 blast frosties in reserve
After seriously considering cancelling this cycle early on, I am thankful every day that we persevered because it has delivered our long awaited BFP!
Mine are complicated... Unfortunately, I have tables summarising my E2 levels, but not my puregon dosage.
Cycle 1 - Started on 150IU for 5 days, no response, did 4 days at 300IU and got too much response and the dose was reduced over the next 4 days. I had no puregon just lucrin the night before my trigger.
We ended up with 26 eggs, 21 were mature, 15 fertilised, 4 made it to blast and were frozen. No fresh transfer, and only 2 of those were able to be used in FETs.
Cycle 2 - Started at 300IU for 2 days, 200 IU for 2 days, 150IU for the next day and then I was in for a blood test. Too much response again so we spent the next 4 days gradually reducing the dosage to nothing. I had no puregon, just lucrin for 2 nights before my trigger and had about 3 doses or orgalutran towards the end trying to keep levels down.
We ended up with 32 eggs, 30 were mature, 20 fertilised, 7 made it to blast and were frozen. No fresh transfer again, and once again we only got to use 2 for FETs.
And that's why you don't want to get OHSS!
Cycle 3 - Started at 200IU for 5 days, was reduced a bit slower and my final dosage was about 50IU the night before trigger.
We got 20 eggs, 12 were mature, 3 fertilised... we transferred at day 3 and got a BFP, the other 2 were frozen.
As I said, complex, complicated and a great demonstration of what you DON'T want to happen! On the third cycle they took me to EPU as soon as I had *some* mature follies, rather than having *most* of them mature. It was all part of the avoiding OHSS plan. I was pretty annoyed at the time, but it seems to have been what my body needed, and I suspect that even though we got very few embryos, they were much better quality eggs this time around.
reading you dosage really surprises me and this whole ivf journey, and how each clinic works differently -
you were on 100 in your first cycle, I was on 300, now I am on 75 on my own, trying naturally - its only 25 iu more, maybe your clinic is more conservative ?
wlb - a lot of it comes down to how you respond. if you have stubborn ovaries (like me) you need high dose to get a minimal response. anything less than 150 i get nothing, even on an IUI cycle aiming for one or two eggs.
M2C has a history of OHSS on IUI's so they would be conservative to stop that happening...
Having PCOS complicates everything. For me, the dosage needs to be high enough to get a response, but there's a VERY fine line between no response and too much response with me. It's always easier to stimulate the ovaries of woman without PCOS as things can be a little more predictable. Some clinics take the cautious approach while others... well... they tend to go to egg collection and freeze all rather than cancel, but this can leave you very sick - I was in hospital for a week after my second EPU.
intrauterine insemination is when you are stimmed to get one or two decent follicles, then triggered (like IVF) but you Ovulate naturally, and your DP's sperm are placed in your uterus via catheter so that they're waiting for the egg. our current pg is from an IUI cycle
Wow it amazing to see how everyone had different size dosages and different reponses
its so interesting, thank you everyone for sharing
ok so i have been doing some thinking and would like to run it past you and let me know what you think??
so we all know that my first cycle was cancelled and i was on 100iu puregon, i had 1 scan which was on day 10 of injecting.
this is what i was thinking about asking fs, if your body chooses the follies within the first few days of injecting, then is there any chance we could try maybe 175/200 iu for the first few days and in them days we will do as many bt's and ultrasounds as he wants and once we can see that we are getting a response, we can lower the dose so we can try and avoid overstimulating.
do you think that this is ok to ask??
i am so desperate to avoid having another cycle cancelled that i am willing to try anything.
M2C, I asked my FS once if it was worth doing earlier blood tests - and he said that there's no point before day 5 of injections. Something about it taking time to get E2 levels up and we won't see it before then. I suspect it may be a similar thing with scans - there's not much point scanning earlier as (particularly if you have polycystic ovaries) it would be hard to tell what's a follicle growing/responding and what's not. It may be worth asking about the step down type cycle that I did - start high to get a response, but keep the dosage reducing to try to avoid an over-response.
I hope that makes sense... I'm not sure I'm expressing myself clearly today.
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what was your dosage?
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