Anyone else receive low PAPP-A results at nuchal scan?

[jessig]

Hi all

I had my 12 week nuchal scan on Friday and the scan itself was perfect, however my PAPP-a results were very low (0.19), putting my baby's risk of down's syndrome at 1:29.

I'm booked in for a CVS on Monday and am extremely worried about the outcome.

Has anyone else had similar results? What happened in your case? I would love to talk to someone in a similar position.

I am 33, this is my first pregnancy after a miscarriage earlier this year.

Thanks
Jess

[melbel]

Our PAPP-A was 0.28 and our combined risk came back at 1:2 so as high as you can get, basically we had a fifty fifty chance of down syndrome. Our CVS was normal and we have a beautiful perfectly healthy baby boy sleeping in the pram next to me to show for it.

Low PAPP-A can also be an indicator of possible heart issues so you will need to have a detailed morphology scan at 20 weeks or so to rule this out...ours was clear. It can also be an indicator that the placenta may no thave attached as well as it should have and this could mean you have a risk of possible IUGR or small for dates baby so you will probably need to have a few growth scans later on to keep an eye on this. there is a small body of research that seems to indicate that taking low dose aspirin and clexane injections can improve blood flow to the placenta and improve baby's gorwth rate...we did this as a preventative measure after consultation with our specialist obstetrician I gave birth to a 4.4kg bouncing baby!

I guess our baby is proof that all of things that could go wrong are just possibilities and things to look out for......they may never happen....in our case we were very very lucky and very blessed that nothing happened.

good luck.....I know how scary that wait for the CVS and then the results is...I will be thinking of you and praying for a good result.....just try and think this way you may have a 1 in 29 chance of a down syndrome baby but you have a 28 in 29 chance that bubba will be perfectly normal......

[jessig]

thank you melbel, that makes me feel a lot more positive. it must have been awfully scary for you too!

thanks for all the information - it's very reassuring to hear how well your pregnancy turned out.

we have our fingers and toes crossed that we will hear good news this thursday.

jess

[Razzberry]

I didn't even have the blood test as my baby had a high nuchal fluid reading at 9 weeks. We had the cvs testing at 11.5weeks and it came back clear and my daughter is asleep in the next room happy and healthy.

I understand just how stressful this time can be, make sure you get plenty of rest after the procedure, as you can be quite crampy and sore. Huge hugs xox

[rene1]

HI,

yes I had a low papp A result (same as yours actually) at my 1st trimester screen and a Downs risk of 1 in 48. I had a CVS done last week and the fish test came back normal. I am awaiting a follow-up appointment with the doctors next week.

Ive done a bit of reading up on low Papp A levels and to be honest it just scared me. I have two healthy boys already, with no hassle pregnancies.

good luck with the next step. il be interested to see how you go

R

[jessig]

Hi

I got my FISH results today and, thank goodness, they are clear. Just need to wait for the full results in two weeks. What a relief!!

Rene1, let me know how you go - i will have to organise my follow-up appt too.

It is scary reading about PAPP-A, i feel like there could be more complications to come, but at least we are through this first hurdle!

Good luck
Jess