Sarah, thyroxine needs to pass undigested into the small intestine to be absorbed properly, so taking it with water 30-60mins before food allows it to "wash" quickly down into the lower digestive system - if you eat or drink anything but water your body closes the valve at the bottom of the stomach, fills with stomach acid and begins to digest it before letting it pass through. In addition, thyroxine binds with calcium and will no longer absorb properly, so taking it with a multivitamin that has calcium in, or a glass of milk, is even worse.

One of the reasons i don't like taking it is because i have to take it and then wait...

Also ITA on the thyroxine brands if you're on a generic. I'm worrying right now because i have to switch generics because of my new doctor (i take a Lloyds generic, and there are no lloyds places near me now) and i don't know how well it's going to work.

Bx