thread: Prednisone and pregnancy?

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  1. #1
    Life Member

    May 2003
    Beautiful Adelaide!
    2,877

    BW,

    My SIL undertook IVF and she took 5mg 3 times a day, 4 times after transfer. I don't know the specifics of her treatment, but she now has a 7 year old little man, my nephew Timmo.

    I have not undertaken fertility treatments, but I was on and off prednisone for some years to treat an autoimmune disease (Sarcoidosis). I was on very high doses of up to 70mg, weaning down to 5mg eventually. (Timing was such that I weaned in a wet cold Adeide winter, which was tough for a few months, but I swam a lot to break through the cycle, IYKWIM?)

    Anyway, my Sarcoidosis physician indicated that prednisone would NOT hinder TTC attempts. Although it then took me 3 years to get pregnant. Of course I will never be sure if they were connected or not. A subsequent OB suggested they might.

    Anyway, I am blabbing now, but it may be worth asking your rheumy about Sarcoidosis? The brief symptoms you describe sound achingly similar.......

  2. #2
    Registered User

    Dec 2005
    6,706

    Lucy, are there any tests that can be done to diagnose sarcoidosis? I've been tested for everything possible, and have been negative for everything. The only thing that shows in my blood tests is an eleveted ESR. I've been given a diagnosis of serum-negative rheumatoid arthritis, which means bugger all, really! What we do know is that I have some sort of inflammatory process going on in my body. It can strike in any and all joints (knees and hands most commonly and usually the most severe, but I've had flares in my spine and my toes and everywhere in between), results in swelling and pain and makes me feel like I can't move even though range of motion isn't affected at all. There's no joint degeneration at all, even after 5 years of this (I feel so very, very fortunate in this!). Does any of that fit sarcoidosis?

    The opinion on prednisone seems very mixed, from what I've found on the net so far. There are some who say it should NOT be taken in pregnancy as it crosses the placenta and may be related to an increased chance of babies having cleft palate. Others say it can't cross the placenta and is safe in pregnancy. While still others say that it can be really useful in preventing miscarriage in some conditions. Looks like I'll have to discuss this thoroughly with both the rheumy and the FS.

    One thing that is worrying me slightly in all this - it appears to have an impact on blood sugar levels, and my insulin resistance is bad enough! That's probably why I gained so much weight on it last time... but I wasn't on metformin then.

    BW