I just wanted to clear something up about the MTX and Folate - No you don't take it on the same DAY as your MTX dose, you take it two days afterwards. Say if you had MTX on Monday, you would start taking your Folate (5mg) on Wednesday, and then for the next 3 days. MTX and Foalte cannot be in your system at the same time. You need to stop folate 2 days before the MTX when it's time for your next dose. For my situation I take MTX on Saturday, then start folate on Mon-Thurs, giving me a 'rest' day on Fri before my next MTX on Sat.